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// Silvia Juliana Trujillo-Caceres 1 , Luisa Torres-Sanchez 1 , Ana I. Burguete-Garcia 2 , Yaneth Citlalli Orbe Orihuela 2 , Ruth Argelia Vazquez-Salas 3 , Esmeralda Alvarez-Topete 4 and Rocio Gomez 4 1 Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica (INSP), Cuernavaca, Morelos, Mexico 2 Centro de Investigacion en Enfermedades Infecciosas, INSP, Cuernavaca, Morelos, Mexico 3 Conacyt-Centro de Investigacion en Salud Poblacional, INSP, Cuernavaca, Morelos, Mexico 4 Departamento de Toxicologia, Cinvestav-IPN, Mexico City, Mexico Correspondence to: Luisa Torres-Sanchez, email: ltorress@insp.mx Keywords: genetic polymorphisms; MSMB; prostate cancer; rs10993994; sexually transmitted diseases Received: July 13, 2018 Accepted: December 16, 2018 Published: January 22, 2019 ABSTRACT Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. MSMB gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Herein, socio-demographic features, sexually transmitted infections records, the reproductive backgrounds, and the genetic characterisation were analysed in 322 incident PC cases and 628 population healthy controls from Mexico City. Whole PC, early-onset PC (PC at < 60 years old), late-onset PC (≥ 60 years old), and PC aggressiveness were used to evaluate the genetic variants contribution to PC risk using unconditional logistic regression models. Overall, none associations between the allelic variants of rs10993994 polymorphisms with whole and PC aggressiveness were found. Howbeit, the TT genotype carriers presented the highest susceptibility to develop early-onset PC (OR = 2.66; 95% CI = 1.41, 5.04; p = 0.03) than CC+CT carriers, both with codominant and recessive models. Although none association between whole PC and MSMB gene polymorphism was found, our results were reinforced by prior studies in European descendent populations, suggesting a contribution between rs10993994 and early-onset PC development.