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Your search keyword '"William Y. Yang"' showing total 3 results
Start Over Author "William Y. Yang" Publisher imr press
3 results on '"William Y. Yang"'

1. Reply to Comment on Shen H, et al. 'Co-signaling receptors regulate T-cell plasticity and immune tolerance'. Frontiers in Bioscience-Landmark. 2019; 24: 96–132

Author

Haitao Shen, Na Wu, Gayani Nanayakkara, Hangfei Fu, Qian Yang, William Y. Yang, Angus Li, Yu Sun, Charles Drummer IV, Candice Johnson, Ying Shao, Luqiao Wang, Keman Xu, Wenhui Hu, Marion Chan, Vincent Tam, Eric T. Choi, Hong Wang, and Xiaofeng Yang

Subjects
Biochemistry, QD415-436, Biology (General), QH301-705.5
Published
2021
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2. Uremic toxins are conditional danger- or homeostasis-associated molecular patterns

Author

Yu Sun, Jun Zhou, Xiaofeng Yang, Xin Wang, Eric T. Choi, Ya-Feng Li, Ying Shao, Gayani Nanayakkara, Yifan Lu, Hong Wang, William Y. Yang, Rongshan Li, Claudette Sanchez, Hangfei Fu, Luqiao Wang, and Candice Johnson

Subjects
0301 basic medicine, medicine.medical_treatment, Caspase 1, Inflammation, Article, 03 medical and health sciences, Downregulation and upregulation, Metabolome, medicine, Alarmins, Homeostasis, Humans, Renal Insufficiency, Chronic, Receptor, Toxins, Biological, Uremia, business.industry, Gene Expression Profiling, Gene expression profiling, 030104 developmental biology, Cytokine, Cardiovascular Diseases, Cancer research, Cytokines, Inflammation Mediators, Signal transduction, medicine.symptom, business, Signal Transduction
Abstract

We mined novel uremic toxin (UT) metabolomics/gene databases, and analyzed the expression changes of UT receptors and UT synthases in chronic kidney disease (CKD) and cardiovascular disease (CVD). We made the following observations: 1) UTs represent only 1/80th of human serum small-molecule metabolome; 2) Some UTs are increased in CKD and CVD; 3) UTs either induce or suppress the expression of inflammatory molecules; 4) The expression of UT genes is significantly modulated in CKD patients, and coronary artery disease (CAD) patients; 5) The expression of UT genes is upregulated by caspase-1 and TNF-alpha pathways but is inhibited in regulatory T cells. These results demonstrate that UTs are selectively increased, and serve as danger signal-associated molecular patterns (DAMPs) and homeostasis-associated molecular patterns (HAMPs) that modulate inflammation. These results also show that some UT genes are upregulated in CKD and CAD via caspase-1/inflammatory cytokine pathways, rather than by purely passive accumulation.

Published
2018

3. Reply to Comment on Shen H, et al. 'Co-signaling receptors regulate T-cell plasticity and immune tolerance'. Frontiers in Bioscience-Landmark. 2019; 24: 96–132

Author

Xiaofeng Yang, Haitao Shen, Charles Drummer, Yu Sun, Ying Shao, Na Wu, Wenhui Hu, Luqiao Wang, Candice Johnson, Marion M. Chan, Keman Xu, Angus Li, Hong Wang, Vincent H. Tam, Qian Yang, Hangfei Fu, William Y. Yang, Eric T. Choi, and Gayani Nanayakkara

Subjects
T cell plasticity, General Immunology and Microbiology, Biology, Receptor, Neuroscience, General Biochemistry, Genetics and Molecular Biology, Immune tolerance
Published
2021

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