1. Management of leptomeningeal malignancy.
- Author
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Pentheroudakis G and Pavlidis N
- Subjects
- Adenocarcinoma pathology, Algorithms, Antimetabolites, Antineoplastic administration & dosage, Antimetabolites, Antineoplastic cerebrospinal fluid, Antimetabolites, Antineoplastic therapeutic use, Antineoplastic Agents, Alkylating administration & dosage, Antineoplastic Agents, Alkylating cerebrospinal fluid, Antineoplastic Agents, Alkylating therapeutic use, Arachnoid Cysts etiology, Arachnoid Cysts radiotherapy, Carcinoma radiotherapy, Carcinoma secondary, Combined Modality Therapy, Cranial Irradiation, Cytarabine administration & dosage, Cytarabine cerebrospinal fluid, Cytarabine therapeutic use, Delayed-Action Preparations, Enzyme Inhibitors therapeutic use, Humans, Injections, Intravenous, Injections, Spinal, Leukemia pathology, Lymphoma pathology, Meningeal Neoplasms radiotherapy, Meningeal Neoplasms secondary, Methotrexate administration & dosage, Methotrexate cerebrospinal fluid, Methotrexate therapeutic use, Palliative Care, Randomized Controlled Trials as Topic, Thiotepa administration & dosage, Thiotepa cerebrospinal fluid, Thiotepa therapeutic use, Topoisomerase I Inhibitors, Topotecan therapeutic use, Arachnoid Cysts drug therapy, Carcinoma drug therapy, Meningeal Neoplasms drug therapy
- Abstract
Leptomeningeal carcinomatosis is defined as malignant infiltration of the pia matter and arachnoid membrane. Leukaemias and lymphomas, lung, breast cancer and melanoma are the primary tumours commonly associated with leptomeningeal carcinomatosis. Diagnosis is based on compatible symptoms and signs, cytological evidence of malignancy in the cerebrospinal fluid, and neuroimaging studies. Treatment is largely palliative (median survival 2-4 months). Patients with lympomatous or leukaemic meningitis, chemosensitive tumours such as breast cancer, low tumour burden, minimal neurological deficits, good performance status and controllable systemic disease survive longer with occasional long-term responses. Available treatment options include focal radiation therapy to CNS sites of bulky, symptomatic or obstructive meningeal deposits, intrathecal cytotoxic therapy and systemic chemotherapy. No evidence of superiority of intrathecal treatment compared with best palliative care (including radiation therapy and systemic treatment) is available from clinical trials. Novel treatment approaches include intrathecal liposomal Ara-C, the development of new cytotoxic compounds, signal transduction inhibitors and monoclonal antibodies for intrathecal or systemic use. Until data from multi-centre randomised trials are available, rationalisation of therapy should be done by stratifying patients to prognostic groups. High-risk patients will only survive for a few weeks and are better managed with supportive measures, whereas low-risk patients justify vigorous cerebrospinal fluid-directed treatment combined with radiation therapy and systemic chemotherapy.
- Published
- 2005
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