1. Which factors influence the ability of a computational model to predict the in vivo deformation behaviour of skeletal muscle?
- Author
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Frank Frank Baaijens, Cwj Cees Oomens, S Sandra Loerakker, Dan L. Bader, and Soft Tissue Biomech. & Tissue Eng.
- Subjects
Muscle tissue ,Tissue deformation ,Materials science ,Finite Element Analysis ,Biomedical Engineering ,Skeletal muscle ,Bioengineering ,General Medicine ,Magnetic Resonance Imaging ,Finite element method ,Computer Science Applications ,Rats ,Human-Computer Interaction ,medicine.anatomical_structure ,In vivo ,Deep tissue ,Models, Animal ,medicine ,Animals ,Humans ,Boundary value problem ,Deformation (engineering) ,Muscle, Skeletal ,Biomedical engineering - Abstract
Deep tissue injury (DTI) is a severe form of pressure ulcer where tissue damage starts in deep tissues underneath intact skin. Tissue deformation may play an important role in the aetiology, which can be investigated using an experimental–numerical approach. Recently, an animal-specific finite element model has been developed to simulate experiments in which muscle tissue was compressed with an indenter. In this study, the material behaviour and boundary conditions were adapted to improve the agreement between model and experiment and to investigate the influence of these adaptations on the predicted strain distribution. The use of a highly nonlinear material law and including friction between the indenter and the muscle both improved the quality of the model and considerably influenced the estimated strain distribution. With the improved model, the required sample size to detect significant differences between loading conditions can be diminished, which is clearly relevant in experiments involving animals.
- Published
- 2013