1. Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis.
- Author
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Sun Y, Liu WZ, Liu T, Feng X, Yang N, and Zhou HF
- Subjects
- Humans, Signal Transduction physiology, Apoptosis physiology, Cell Differentiation physiology, Cell Movement physiology, Cell Proliferation physiology, Cellular Senescence physiology, Extracellular Signal-Regulated MAP Kinases metabolism, Mitogen-Activated Protein Kinases metabolism
- Abstract
The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.
- Published
- 2015
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