1. Optimization of nutraceutical coenzyme Q10 nanoemulsion with improved skin permeability and anti-wrinkle efficiency
- Author
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Abeer M. Khattab, Eman S. El-Leithy, Doaa G. Hussein, and Amna M. A. Makky
- Subjects
Antioxidant ,Surface Properties ,Ubiquinone ,Chemistry, Pharmaceutical ,Skin Absorption ,medicine.medical_treatment ,Pharmaceutical Science ,02 engineering and technology ,Skin permeability ,Administration, Cutaneous ,030226 pharmacology & pharmacy ,Surface-Active Agents ,03 medical and health sciences ,chemistry.chemical_compound ,Drug Delivery Systems ,0302 clinical medicine ,Nutraceutical ,Drug Stability ,Drug Discovery ,medicine ,Animals ,Particle Size ,Rats, Wistar ,Pharmacology ,Coenzyme Q10 ,Chromatography ,Viscosity ,Organic Chemistry ,Hydrogen-Ion Concentration ,021001 nanoscience & nanotechnology ,Rats ,Skin Aging ,Drug Liberation ,Solubility ,chemistry ,Anti wrinkle ,Permeability (electromagnetism) ,Nanoparticles ,Emulsions ,Female ,0210 nano-technology - Abstract
Coenzyme Q10 (CoQ10) is an insoluble, poorly permeable antioxidant with great biological value which acts as anti-aging and anti-wrinkle agent. To improve its permeability through topical application, the current study aimed at formulating oil/water (o/w) nanoemulsion (NE) as an efficient vehicle for delivering (CoQ10) through the skin barriers. The solubility of (CoQ10) was tested for various oils, surfactants (S), and co-surfactants (CoS). The NE region was determined by constructing pseudoternary phase diagrams. NE formulae containing 1, 2, and 3% w/w drug have been subjected to thermodynamic stability test. The formulae that passed thermodynamic stability tests were characterized by physical properties as pH, viscosity, refractive index, droplet size, zeta-potential, TEM, electroconductivity, in vitro release, and ex vivo permeation. The formula 'F2' containing 10% w/w isopropyl myristate (oil phase), 60% w/w of Tween 80: Transcutol HP mixture (S/CoS
- Published
- 2017
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