1. Adeno-associated virus type 2 as an oncogenic virus in human hepatocellular carcinoma
- Author
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Jessica Zucman-Rossi, Sandrine Imbeaud, Shalini Datta, Jean-Charles Nault, and Andrea Franconi
- Subjects
0301 basic medicine ,Cancer Research ,viruses ,DNA virus ,Biology ,medicine.disease ,Insertional mutagenesis ,03 medical and health sciences ,Cyclin E1 ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,medicine ,Cancer research ,Molecular Medicine ,Telomerase reverse transcriptase ,Adeno-Associated Virus Type 2 ,Author's View ,Oncovirus ,Cyclin A2 - Abstract
Adeno-associated virus type 2 (AAV2) is a defective DNA virus that was previously considered to be non-pathogenic. We identified somatic AAV2 integration in a subset of 11 hepatocellular carcinomas (HCC) that mainly developed in normal liver without known etiology through recurrent insertional mutagenesis in cancer driver genes such as telomerase reverse transcriptase (TERT), cyclin A2 (CCNA2), cyclin E1 (CCNE1), tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10), and lysine (K)-specific methyltransferase 2B (KMT2B).
- Published
- 2016
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