1. Resistance to Lipophilic Cationic Compounds in Multidrug Resistant Leukemia Cells
- Author
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Nili Ramu and Avner Ramu
- Subjects
Cancer Research ,Leukemia P388 ,Chemistry ,Drug Resistance ,Cationic polymerization ,Antineoplastic Agents ,Growth inhibitory ,Hematology ,medicine.disease ,Membrane Potentials ,Quaternary Ammonium Compounds ,Multiple drug resistance ,Mice ,Structure-Activity Relationship ,Leukemia ,Solubility ,Oncology ,Biochemistry ,Molecular size ,Lipophilicity ,Tumor Cells, Cultured ,medicine ,Animals ,Cell Division - Abstract
Previously we have shown that multidrug resistant cells are cross-resistant to certain permanently charged cationic lipophilic compounds. In the present study we extend these observations to additional cationic lipophilic compounds with unrelated chemical structures. Study of the growth inhibitory activity of series of triphenylalkyl-phosphonium and alkyl-ammonium compounds revealed that cross-resistance to these compounds in multidrug resistant P-388 murine leukemia cells, was related to the presence of cationic charge but not to the molecular size/degree of lipophilicity.
- Published
- 1993
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