1. Biocompatibility of Modified Bionanocellulose and Porous Poly(ϵ-caprolactone) Biomaterials
- Author
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Karolina Kowalska-Ludwicka, Agnieszka Adamus, Radoslaw A. Wach, Stanisław Bielecki, Zbigniew Pasieka, Marek Kolodziejczyk, Janusz M. Rosiak, Bartlomiej Grobelski, and Alicja Olejnik
- Subjects
Materials science ,Polymers and Plastics ,Biocompatibility ,General Chemical Engineering ,Inflammation ,ϵ caprolactone ,In vitro ,Analytical Chemistry ,In vivo ,medicine ,medicine.symptom ,Cytotoxicity ,Porosity ,Biomedical engineering ,Explant culture - Abstract
Biocompatibility of modified bionanocellulose (BC) and porous poly(ϵ caprolactone) (PCL) were compared to UHMWPE. For all the materials lack of cytotoxic effect to mouse fibroblasts was observed in vitro. In vivo study, subcutaneous implantations in Wistar rats, lasted for seven, 14, and 30 days. Subsequently the composition of surrounding tissue and explants surface changes was evaluated. No symptoms of acute inflammation were observed. Surrounding tissue thickness, the number of granulocytes, lymphocytes, macrophages, and blood vessels differed in time and revealed regular healing process. It is concluded that investigated PCL and BC are the materials with superior biocompatibility with high application potential.
- Published
- 2014