1. 19F Oximetry with semifluorinated alkanes
- Author
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Lothar R. Schad, Stefan Kegel, Bastian Theisinger, Jorge Chacon-Caldera, Charalambos Tsagogiorgas, and Gerhard Glatting
- Subjects
Alkane ,chemistry.chemical_classification ,Calibration curve ,Chemistry ,Biomedical Engineering ,Analytical chemistry ,Pharmaceutical Science ,Medicine (miscellaneous) ,chemistry.chemical_element ,Saturation recovery ,Hexafluorobenzene ,General Medicine ,Oxygen ,030218 nuclear medicine & medical imaging ,Oxygen tension ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Linear relationship ,030220 oncology & carcinogenesis ,Fluorine ,Organic chemistry ,Biotechnology - Abstract
This work examines the variation of longitudinal relaxation rate R1(= 1/T1) of the 19F-CF3-resonance of semifluorinated alkanes (SFAs) with oxygen tension (pO2), temperature (T) and pH in vitro. Contrary to their related perfluorocarbons (PFCs), SFA are amphiphilic and facilitate stable emulsions, a prerequisite for clinical use. A linear relationship between R1 and pO2 was confirmed for the observed SFAs at different temperatures. Using a standard saturation recovery sequence, T1 has been successfully measured using fluorine 19F-MRI with a self-constructed birdcage resonator at 9.4 T. A calibration curve to calculate pO2 depending on T and R1 was found for each SFA used. In contrast to the commonly used PFC, SFAs are less sensitive to changes in pO2, but more sensitive to changes in temperature. The influence of pH to R1 was found to be negligible.
- Published
- 2015
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