18 results on '"Chunxue Bai"'
Search Results
2. Lung function and long-term safety of tiotropium/olodaterol in East Asian patients with chronic obstructive pulmonary disease
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Roland Buhl, Ulrich Bothner, Chunxue Bai, Yihua Zhao, Kwan Ho Lee, Olaf Jöns, Masakazu Ichinose, and Sang Haak Lee
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Male ,Time Factors ,Health Status ,Vital Capacity ,Cholinergic Antagonists ,Pulmonary function testing ,Pulmonary Disease, Chronic Obstructive ,chemistry.chemical_compound ,0302 clinical medicine ,Forced Expiratory Volume ,030212 general & internal medicine ,Lung ,Lung function ,Original Research ,COPD ,education.field_of_study ,pulmonary function ,Olodaterol ,Area under the curve ,General Medicine ,Middle Aged ,humanities ,Bronchodilator Agents ,Drug Combinations ,Treatment Outcome ,Area Under Curve ,Female ,China ,medicine.medical_specialty ,Population ,International Journal of Chronic Obstructive Pulmonary Disease ,03 medical and health sciences ,Asian People ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Tiotropium Bromide ,Adverse effect ,education ,Adrenergic beta-2 Receptor Agonists ,Aged ,business.industry ,Recovery of Function ,medicine.disease ,Benzoxazines ,respiratory tract diseases ,Clinical trial ,030228 respiratory system ,chemistry ,Quality of Life ,adverse effects ,TONADO® ,business ,human activities - Abstract
Background and purpose While the efficacy and safety of combined tiotropium and olodaterol in patients with COPD was established in a large clinical trial program, it is important to assess whether clinical data can be applied to geographic patient groups, particularly for East Asian patients who may have a different phenotypic profile to the global trial population. This study aimed to compare the lung function and safety profiles of tiotropium/olodaterol and monocomponents in East Asian and global populations from the TONADO® trials. Materials and methods In the replicate, double-blind, parallel-group, active-controlled, randomized, 52-week, Phase III TONADO studies, patients received tiotropium/olodaterol, tiotropium, or olodaterol. We assessed the forced expiratory volume in 1 second (FEV1) area under the curve from 0 to 3 hours (AUC0–3) response and trough FEV1 response at 24 weeks for the approved doses, tiotropium/olodaterol 5/5 μg, tiotropium 5 μg, and olodaterol 5 μg. Treatment-emergent adverse events were recorded throughout treatment and ≤21 days after study medication. Results In the East Asian population, 1,152 patients were randomized (5,163 overall). After 24 weeks, FEV1 AUC0–3 and trough FEV1 responses were greater (P, Video abstract
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- 2017
3. Marked Reduction in 28-Day Mortality Among Elderly Patients with Severe Community-Acquired Pneumonia: Post Hoc Analysis of a Large Randomized Controlled Trial [Corrigendum]
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Yan Liu, Chi Zhang, Chengyu Li, Chunxue Bai, and Hongcai Shang
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Clinical Interventions in Aging ,General Medicine ,Geriatrics and Gerontology - Abstract
Liu Y, Zhang C, Li C, Bai C, Shang H. Clin Interv Aging.2020;15:2109–2115. Page 2111, Results, third paragraph, second sentence, thetext “Elderly patients with XBJ had a significantly inferioroverall survival to those with placebo” should read“Elderly patients with placebo had a significantly inferior overall survival to those with XBJ”. Page 2114, Figure 1 caption, the text “elderly group:patients with XBJ had a significantly inferior overall survivalto those who with placebo” should read “elderlygroup: patients with placebo had a significantly inferioroverall survival to those with XBJ”. The authors apologize for these errors and advise they do notchange the scientific conclusions of the article in any way. Read the original article
- Published
- 2020
4. Deposition of insoluble elastin by pulmonary fibroblasts from patients with COPD is increased by treatment with versican siRNA
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Chunxue Bai, Jing Zhang, Lian Wu, Mervyn J. Merrilees, and Jie Ming Qu
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0301 basic medicine ,Small interfering RNA ,Time Factors ,Down-Regulation ,elastin ,International Journal of Chronic Obstructive Pulmonary Disease ,Transfection ,030226 pharmacology & pharmacy ,Cell Line ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,chemistry.chemical_compound ,Versicans ,0302 clinical medicine ,Tropoelastin ,medicine ,Humans ,COPD ,RNA, Small Interfering ,pulmonary fibroblasts ,Fibroblast ,Lung ,Original Research ,versican ,Gene knockdown ,integumentary system ,biology ,business.industry ,General Medicine ,Fibroblasts ,respiratory tract diseases ,carbohydrates (lipids) ,RNAi Therapeutics ,030104 developmental biology ,medicine.anatomical_structure ,Solubility ,chemistry ,Chondroitin sulfate proteoglycan ,Case-Control Studies ,Gene Knockdown Techniques ,Immunology ,Cancer research ,biology.protein ,Versican ,RNA Interference ,business ,Elastin - Abstract
Lian Wu,1,2 Jing Zhang,3 Jie Ming Qu,4 Chun-xue Bai,3 Mervyn J Merrilees5 1Department of Community and Health Services, Unitec, 2Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand; 3Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 4Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 5Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand Abstract: A reduced content of alveolar elastic fibers is a key feature of COPD lung. Despite continued elastogenic potential by alveolar fibroblasts in the lung affected by COPD, repair of elastic fibers does not take place, which is due to increased levels of the chondroitin sulfate proteoglycan versican that inhibits the assembly of tropoelastin into fibers. In this study, primary pulmonary fibroblast cell lines from COPD and non-COPD patients were treated with a small interfering RNA (siRNA) against versican to determine if knockdown of versican could restore the deposition of insoluble elastin. Versican siRNA treatment reduced versican expression and secretion by pulmonary fibroblasts from both COPD and non-COPD patients (P
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- 2017
5. Risk factors for FEV1 decline in mild COPD and high-risk populations
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Bing Li, Jian Zhou, Changhui Wang, Chunxue Bai, Yutong Gu, Guochao Shi, Huiping Li, Shujing Chen, Jing Zhang, and Yuanlin Song
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Spirometry ,COPD ,medicine.medical_specialty ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Population ,General Medicine ,Odds ratio ,medicine.disease ,respiratory tract diseases ,Pulmonary function testing ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Internal medicine ,Epidemiology ,medicine ,Physical therapy ,030212 general & internal medicine ,Expiration ,business ,education ,Chi-squared distribution - Abstract
Background Early diagnosis of COPD is often not achieved due to limited recognition and limited access to the pulmonary function test. Our hypothesis was that lung function decline may be different between populations with mild COPD and those who are at high risk and do not receive treatment. Patients and methods Subjects with mild COPD and those from a high-risk COPD population were recruited from a community-based COPD epidemiological study after obtaining consent. Baseline clinical characteristics, symptom questionnaire, spirometry, low-dose computed tomography (LDCT) chest scan, and blood plasma biomarker data were collected initially and then 1 year later. Results A total of 617 participants were recruited, and 438 eventually completed the first-year follow-up visit; 72 participants (46 males) were in the mild COPD group, and 225 participants (165 males) were in the high-risk group. The mean forced expiratory volume in the first second of expiration (FEV1) decline in the mild COPD group was 129 mL, which was significantly higher than the 30 mL decline in the high-risk population group (P=0.005). Group category (odds ratio [OR] =0.230) and COPD Assessment Test (CAT) score (OR =9.912) were independent risk factors for an FEV1% predicted decline of >15% for all participants. In the mild COPD group, patients with a higher CAT (OR =5.310) and Emphysema Index (OR =5.681) were associated with a FEV1% predicted decline of >15% at the first-year follow-up. No factor showed a significantly predictive effect on FEV1 decline in the high-risk COPD group. Conclusion Group category was an independent influential factor associated with FEV1 decline.
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- 2017
6. The implication of telehealthcare in COPD management of China
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Jing Zhang, Chunxue Bai, and Xiangda Lao
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Pulmonary and Respiratory Medicine ,China ,medicine.medical_specialty ,Telemedicine ,Internet privacy ,Health Services Accessibility ,Pulmonary Disease, Chronic Obstructive ,Humans ,Immunology and Allergy ,Medicine ,Disease management (health) ,Internet ,COPD ,Delivery of Health Care, Integrated ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,Disease Management ,Prognosis ,medicine.disease ,Systems Integration ,Information and Communications Technology ,Physical therapy ,System integration ,The Internet ,business - Abstract
Chronic obstructive pulmonary disease (COPD) is a very common disease all around the world and has become an increasing public health concern to the Chinese medical community. In the past decades, telehealthcare technology has become a good way to manage COPD but current evidence makes it hard to determine the effectiveness of this technology. Internet of things (Iot) is a recent breakthrough in communication technology, which links the virtual world to the real world through connection between sensors and working devices. It relates people and items in any ways so that data collection and management become more flexible. Our review concentrates on the effectiveness and potential application of telehealthcare in COPD management and how IoT technology may stimulate COPD healthcare delivery through telehealthcare technology.
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- 2013
7. Potential significance of telocytes in the pathogenesis of lung diseases
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Chunxue Bai, Yonghua Zheng, and Xiangdong Wang
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Lung Diseases ,Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Cell type ,Cell signaling ,Bronchiole ,Lung ,biology ,Public Health, Environmental and Occupational Health ,CD34 ,Vimentin ,Cell Communication ,respiratory system ,respiratory tract diseases ,medicine.anatomical_structure ,Telocyte ,medicine ,biology.protein ,Animals ,Humans ,Immunology and Allergy ,Cell Surface Extensions ,Stem cell - Abstract
Multiple cells play critical roles in the pathogenesis of lung diseases, even though the exact mechanisms are still not clear. Telocytes are characterized by telopodes, which are thin and long prolongations, and a small amount of cytoplasm rich with mitochondria, as shown by immune-positive staining against CD34, c-kit and vimentin. Telocytes have been found in many organs of mammals, including the trachea and lung. This report summarizes the latest findings associated with telocytes, with a special focus on the lung, and demonstrates that telocytes exist in the smooth muscle layer under cartilage and bronchiole in the lung, and also in the interstitial space of alveoli. Telocytes have a mediate connection with epithelial cells and direct connection with smooth muscle cells both in blood vessels and bronchiole in the lung. Telocytes also have a close relationship with other cell types, such as immune cells and stem cells. Telopodes appear with dichotomous branching and alternation of podom and podomer, forming a 3D network structure with complex homo- and hetero-cellular junctions. All characteristics of telocytes in lung tissue indicate that telocytes may play a potential, but important, role in the pathogenesis of lung diseases.
- Published
- 2012
8. ADAM33Gene Polymorphisms Associate with Asthma Susceptibility and Severity in East China Han Population
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Meiling Jin, Zhilin Hu, Chunxue Bai, and Zhijun Jie
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Adult ,Male ,Pulmonary and Respiratory Medicine ,China ,Adolescent ,Genotype ,ADAM33 ,Single-nucleotide polymorphism ,Polymorphism, Single Nucleotide ,Young Adult ,Asian People ,Gene Frequency ,Polymorphism (computer science) ,Humans ,Immunology and Allergy ,Medicine ,Genetic Predisposition to Disease ,Allele frequency ,Aged ,Asthma ,Genetics ,business.industry ,Haplotype ,Middle Aged ,medicine.disease ,respiratory tract diseases ,ADAM Proteins ,Haplotypes ,Pediatrics, Perinatology and Child Health ,Immunology ,Female ,Restriction fragment length polymorphism ,business ,Polymorphism, Restriction Fragment Length - Abstract
Multiple genetic and environmental factors impact the pathogenesis of asthma. ADAM33 (a disintegrin and metalloproteinase domain 33) represents a novel susceptibility gene for asthma in several diverse populations. The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) of the ADAM33 gene associate with asthma susceptibility and severity in the Chinese Han population.A total of 224 subjects were enrolled, including 74 normal controls and 150 asthmatic patients. The asthmatic enrollees were further categorized into high- or low-severity groups according to the percentage of forced expiratory volume in 1 second of predicted value, symptoms, nighttime awakening, requirement for short-acting β2-agonist, and interference with normal activities. Six SNPs (F + 1, ST + 4, S1, S2, T1, and T2) in ADAM33 were genotyped using the polymerase chain restriction fragment length polymorphism method.Three SNPs (F + 1, T1, and T2) of ADAM33 were found to have significant associations with asthma in the study population (p = .0058-.0067). The allele frequencies of two SNPs (F + 1, T1) in both the low- and high-severity groups were significantly different from the allele frequency in the control group. The allelic frequency of the T2 SNP was significantly different from that of the control group only in the high-severity group (p = .0081). Haplotype analysis demonstrated that the frequency of 7575G, 12433T, and 12462C (GTC haplotype) is higher in healthy controls than amongst asthma patients (78.4% vs. 61.8%, p = .0004).Polymorphisms of the ADAM33 gene associate with asthma susceptibility in the east China Han population, and the genetic association is stronger in high-severity asthmatics.
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- 2011
9. Potential clinical application of KGF-2 (FGF-10) for acute lung injury/acute respiratory distress syndrome
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Chunxue Bai, Xiaocong Fang, and Xiangdong Wang
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Pathology ,medicine.medical_specialty ,ARDS ,Lung ,business.industry ,General Medicine ,Disease ,respiratory system ,Lung injury ,medicine.disease ,Fibroblast growth factor ,respiratory tract diseases ,Epithelial Damage ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,medicine ,Pharmacology (medical) ,Keratinocyte growth factor ,General Pharmacology, Toxicology and Pharmaceutics ,Diffuse alveolar damage ,business - Abstract
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an acute life-threatening form of hypoxemic respiratory failure with a high mortality rate, and there is still a great need for more effective therapies for such a severe and lethal disease. Dysfunction of endothelial and epithelial barriers is one of the most important mechanisms in hypoxia-associated ALI/ARDS. The acceleration of the epithelial repair process in the injured lung may provide an effective therapeutic target. KGF-2, a potent alveolar epithelial cell mitogen, plays an important role in organ morphogenesis and epithelial differentiation, and modulates a variety of mechanisms recognized to be important in alveolar repair and resolution in ALI/ARDS. Preclinical and clinical studies have suggested that KGF-2 may be the candidate of novel therapies for alveolar epithelial damage during ALI/ARDS.
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- 2010
10. Role of 5-lipoxygenase and its production of leukotriene B4in innate host defense and diseases
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Chunxue Bai and Xiangdong Wang
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biology ,Physiology ,Leukotriene B4 ,Mucociliary clearance ,Chemotaxis ,Inflammation ,Critical Care and Intensive Care Medicine ,Critical Care Nursing ,Mucus ,chemistry.chemical_compound ,chemistry ,Arachidonate 5-lipoxygenase ,Immunology ,biology.protein ,medicine ,Secretion ,Arachidonic acid ,medicine.symptom ,Molecular Biology - Abstract
5-Lipoxygenase (5-LO) is an important enzyme that dominates the metabolism of arachidonic acid and the synthesis of leukotrienes, of which leukotriene B4 (LTB4) is suggested to be one of the most potent chemoattractants and activators of leukocytes. 5-LO is normally limited to hematopoetic cells, e.g. granulocytes and macrophages, where LTB4 is produced. Leukotrienes play an important role in the innate defense system, in the antimicrobial defense system, and in intercellular signaling. Under pathophysiological conditions, overproduction of LTB4 was noted in multiple cells. It is known that 5-LO and its production of LTB4 are involved in the maintenance of normal host defense, initiation of inflammation, migration of leukocytes, development of endothelial barrier dysfunction, hyperresponsiveness of smooth muscle cells, stimulation of mucus secretion, reduction of mucociliary clearance, and tissue remodeling. In order to understand the role of 5-LO and its production in functions of the innate host defense...
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- 2009
11. Role of enteral ebselen and ethylhydroxyethyl cellulose in pancreatitis-associated multiple-organ dysfunction in humans
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Xiangdong Wang, Li-Ming Zhao, Chunxue Bai, Hong-Guang Lu, and Yu-Be Shi
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medicine.medical_specialty ,Lung ,Physiology ,business.industry ,Ebselen ,Organ dysfunction ,Critical Care and Intensive Care Medicine ,Critical Care Nursing ,medicine.disease ,Gastroenterology ,Enteral administration ,Surgery ,chemistry.chemical_compound ,Parenteral nutrition ,medicine.anatomical_structure ,chemistry ,Internal medicine ,medicine ,Pancreatitis ,Acute pancreatitis ,medicine.symptom ,business ,Multiple organ dysfunction syndrome ,Molecular Biology - Abstract
Objective. Acute pancreatitis (AP) remains a severe disease responsible for the development of multiple organ dysfunction, and is associated with high mortality and morbidity. Early enteral nutrition has been suggested to have therapeutic potential for improving the outcome of AP patients. The aim of this study was to investigate whether supplementation of enteral nutrition with ebselen and ethylhydroxyethyl cellulose (EHEC) can attenuate the acute-phase responses and the severity of organ dysfunction in AP patients with either single- or multiple-organ dysfunction. Material and methods. AP patients with single-organ dysfunction (acute lung dysfunction) were treated with either vehicle (n=43) or the combination of ebselen and EHEC (n=48). AP patients with multiple-organ dysfunction (more than two organs) were treated with either vehicle (n=52) or the combination of ebselen and EHEC (n=55). Results. The combination of ebselen and EHEC significantly reduced the occurrence of infection (as indicated by a low...
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- 2008
12. Airway epithelial dysfunction in the development of acute lung injury and acute respiratory distress syndrome
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Kenneth B. Adler, Xiangdong Wang, Chunxue Bai, and Jonas S. Erjefält
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Pulmonary and Respiratory Medicine ,ARDS ,Pathology ,medicine.medical_specialty ,Lung ,business.industry ,Public Health, Environmental and Occupational Health ,Inflammation ,respiratory system ,Lung injury ,medicine.disease ,Systemic inflammation ,respiratory tract diseases ,Pathogenesis ,medicine.anatomical_structure ,Immunology and Allergy ,Medicine ,medicine.symptom ,business ,Airway ,Diffuse alveolar damage - Abstract
Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are common and important stages of both pulmonary and systemic critical illnesses. ALI/ARDS is categorized as primary or secondary based on the etiology of the disease. There is increasing evidence to suggest the involvement of airway epithelial cells in the pathogenesis of ALI/ARDS. The airway epithelial cell is a new candidate as a biological target responsible for development of the disease and the role of these cells in the pathogenesis of ALI/ARDS is under investigation. This review describes the importance of the airway epithelial cell in the development of ALI/ARDS, its role as the first line of lung defense facing local and primary challenges, its role as an important player in the development of airway inflammation and remodeling, as an inflammatory promoter for initiating both local and systemic inflammation and as an active producer of several inflammatory and anti-inflammatory mediators. It is hypothesized that airway epithelial cells may contribute to ALI/ARDS via Toll-like receptor-involved mediators, reactive oxygen species-involved reactions and an imbalance between protease and antiprotease activation. The airway epithelial cell may be a valuable therapeutic target for discovering and developing new drugs and/or new therapeutic strategies for ALI/ARDS.
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- 2007
13. Multiple-organ dysfunction syndrome in China
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Chunxue Bai, J. Lewis, and J. Y. Sun
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medicine.medical_specialty ,Lipopolysaccharide ,Physiology ,business.industry ,Inflammatory response ,Critical Care and Intensive Care Medicine ,Critical Care Nursing ,medicine.disease ,Enteral administration ,Pathogenesis ,chemistry.chemical_compound ,Therapeutic approach ,chemistry ,Supportive psychotherapy ,medicine ,Multiple organ dysfunction syndrome ,Intensive care medicine ,Receptor ,business ,Molecular Biology - Abstract
In this article we review the current status of multiple-organ dysfunction syndrome (MODS) in China, with a focus on its epidemiology and pathogenesis and clinical treatment approaches. Current and future research directions are also reviewed with the overall goal of improving our understanding of this disorder so that optimal prevention and treatment strategies can be developed. Pathogenically, Chinese scholars hypothesize that MODS occurs in accordance with a “two-hit” model, which results in an overwhelming systemic inflammatory response within the host. Lipopolysaccharide or endotoxin activates several intracellular signaling pathways via cellular membrane receptors, thereby contributing to this inflammatory response. Supportive therapy of vital organs represents the main therapeutic approach for these patients, although nutritional support in the form of early enteral feeding is also important. Additional approaches include the administration of agents to increase the rate of protein synthesis and mo...
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- 2006
14. Potential factors of interorgan signals in the development of pancreatitis-associated acute lung injury and acute respiratory distress syndrome
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Xiangdong Wang, Hong Zhao, Chunxue Bai, and Xia Zhao
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Pathology ,medicine.medical_specialty ,ARDS ,Physiology ,business.industry ,Inflammation ,Acute respiratory distress ,Lung injury ,Critical Care and Intensive Care Medicine ,Critical Care Nursing ,medicine.disease ,medicine.anatomical_structure ,Immunology ,medicine ,Pancreatitis ,Acute pancreatitis ,medicine.symptom ,Diffuse alveolar damage ,Pancreas ,business ,Molecular Biology - Abstract
The incidence of the pulmonary complications in patients with acute pancreatitis is up to 60%, from mild hypoxaemia without clinical or radiological abnormalities to severe acute lung injury. Although a number of reviews has described clinical evidence of pancreatitis-associated lung injury (PALI), there is still a lack of information on potential interorgan signalling involved in the development of PALI. The present review discusses the potential factors that have been considered as candidates responsible for interorgan signalling coupling pancreatitis to lung injury. Inflammatory mediators produced from the pancreas, leucocyte system and extrapancreatic organs may directly or indirectly contribute to the high concentration in the circulation, activate circulating leucocytes, initiate the inflammatory responses of pulmonary resident cells or induce acute lung injury. Circulating leucocytes have been suggested to play an important role in interorgan signalling during the development of PALI, by producing ...
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- 2005
15. ACUTE CARDIOPULMONARY EFFECTS OF A DUAL–ENDOTHELIN RECEPTOR ANTAGONIST ON OLEIC ACID–INDUCED PULMONARY ARTERIAL HYPERTENSION IN DOGS
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Chunxue Bai, Ling Wang, Michael A. Matthay, Xiao Su, Lorraine B. Ware, and Du Ming Zhu
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Endothelin Receptor Antagonists ,Pulmonary and Respiratory Medicine ,Pulmonary Circulation ,Cardiac output ,Pyridines ,Hypertension, Pulmonary ,Vasodilator Agents ,Clinical Biochemistry ,Tetrazoles ,Pulmonary Artery ,Lung injury ,Random Allocation ,Dogs ,Tezosentan ,medicine ,Animals ,Molecular Biology ,Pulmonary Gas Exchange ,Endothelin receptor antagonist ,business.industry ,medicine.disease ,Pulmonary hypertension ,Oxygen ,Blood pressure ,medicine.anatomical_structure ,Pulmonary Veins ,Anesthesia ,Acute Disease ,Respiratory Mechanics ,Vascular resistance ,Endothelin receptor ,business ,Oleic Acid ,medicine.drug - Abstract
The objective of this study was to evaluate the cardiopulmonary effects of a dual-endothelin (ET) receptor antagonist, Tezosentan, on oleic acid (OA)-induced acute lung injury with pulmonary arterial hypertension in dogs. Twelve pentobarbital-anesthetized dogs with intravenous OA-induced acute lung injury (ALI) were divided into 2 groups. The control group (n=6) received saline treatment, whereas the treatment group (n=6) received the ET receptor antagonist, Tezosentan (1 mg/kg intravenous [i.v.]+1 mg/kg/h i.v. infusion). Cardiopulmonary parameters were monitored continuously for 1 hour. OA administration resulted in a significant increase in mean pulmonary arterial pressure (MPAP) and pulmonary vascular resistance (PVR) and a decrease in mean systemic arterial pressure (MSAP), systemic vascular resistance (SVR), and cardiac output (CO) in all dogs. Tezosentan treatment markedly attenuated the pulmonary hypertension, with a 32% decrease in MPAP (from 23 +/- 2 mm Hg to 15 +/- 2 mm Hg; P.01) and a 22% decrease in PVR (from 860 +/- 105 dyn.s.cm(-5) to 670 +/- 96 dyn.s.cm(-5); P.01) at the end of study. MSAP and SVR were unchanged after Tezosentan treatment, and there was an increase in cardiac output and a decline in peak inspiratory pressure (PIP) in the Tezosentan group compared with the control group. These results indicate that the dual-ET receptor antagonist, Tezosentan, can attenuate the pulmonary hypertension induced by OA. Thus, dual-ET receptor antagonists such as Tezosentan may be useful in the management of acute pulmonary arterial hypertension, complicating the course of OA-induced lung injury.
- Published
- 2004
16. Increased serum levels of lipocalin-1 and -2 in patients with stable chronic obstructive pulmonary disease
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Qing-hua Kong, Chunxue Bai, Wei Xia, Shui Gao, Xiao-ru Wang, Kun Gao, Jing Zhang, Hui Qi, Ling Wu, Jieming Qu, and Yongpu Li
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Male ,China ,medicine.medical_specialty ,Cross-sectional study ,International Journal of Chronic Obstructive Pulmonary Disease ,Severity of Illness Index ,Gastroenterology ,chronic obstructive pulmonary disease ,Pulmonary Disease, Chronic Obstructive ,Proto-Oncogene Proteins ,Internal medicine ,Humans ,Medicine ,Prospective Studies ,Prospective cohort study ,Original Research ,Aged ,Aged, 80 and over ,COPD ,lipocalin-1 ,business.industry ,lipocalin-2 ,Acute-phase protein ,Case-control study ,biomarkers ,General Medicine ,Middle Aged ,medicine.disease ,Lipocalins ,Obstructive lung disease ,Up-Regulation ,Cross-Sectional Studies ,Case-Control Studies ,Immunology ,Female ,Inflammation Mediators ,business ,Body mass index ,Acute-Phase Proteins ,Lipocalin 1 ,Cohort study - Abstract
Xiao-ru Wang,1,* Yong-pu Li,2,* Shui Gao,2 Wei Xia,2 Kun Gao,1 Qing-hua Kong,1 Hui Qi,1 Ling Wu,1 Jing Zhang,3 Jie-ming Qu,4 Chun-xue Bai3 1Department of Pulmonary Medicine, Dahua Hospital, Xuhui District, Shanghai, 2Department of Pulmonary Medicine, People's Hospital of Changshou, Chongqing, 3Department of Pulmonary Medicine, Zhongshan Hospital, 4Department of Pulmonary Medicine, Huadong Hospital, Fudan University, Shanghai, People's Republic of China *These two authors contributed to this paper equally Abstract: Despite a number of studies on biomarkers in chronic obstructive pulmonary disease (COPD), only a few disease-related markers have been identified, yet we still have no satisfactory markers specific to innate immune system and neutrophil activation, which is essential in airway inflammation in COPD. Recent biological studies indicated that lipocalins (LCNs) might be involved in airway inflammation and innate immunity; however, results from available studies on the association of LCNs with COPD are not consistent. We carried out a multicenter prospective observational cohort study to investigate the differences in serum levels of LCN1 and LCN2 between subjects with COPD (n=58) and healthy controls (n=29). Several validated inflammatory markers, including C-reactive protein, tumor necrosis factor-a, interleukin-6, and interleukin-8, were measured. The correlation of LCN1 and LCN2 with clinical features such as smoking habits, lung function, symptoms, and disease category was also analyzed. When comparing with healthy controls, serum levels of LCN1 (66.35±20.26 ng/mL versus 41.16±24.19 ng/mL, P
- Published
- 2014
17. Multiple-systems dysfunction within the lung: A new angle for understanding pulmonary dysfunction
- Author
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Xiangdong Wang and Chunxue Bai
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medicine.medical_specialty ,Lung ,medicine.anatomical_structure ,Physiology ,business.industry ,Internal medicine ,Cardiology ,Medicine ,Critical Care and Intensive Care Medicine ,Critical Care Nursing ,business ,Pulmonary Dysfunction ,Molecular Biology - Published
- 2006
18. Primary care physician perceptions on the diagnosis and management of chronic obstructive pulmonary disease in diverse regions of the world
- Author
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Gilbert Nadeau, Otto Bauerle, Charles Feldman, Chunxue Bai, Grant W. Waterer, Shu Hashimoto, José Roberto Jardim, Rafael Laniado-Laborín, Christopher K.W. Lai, Richard D Walters, Zaurbek Aisanov, Abdullah Sayiner, Ying-Huang Tsai, Federico D Colodenco, Jae Jeong Shim, Pulmonol Res Inst, Fudan Univ, Ctr Med Amer, Hosp Rehabil Resp Maria Ferrer, Charlotte Maxeke Johannesburg Hosp, Univ Witwatersrand, Nihon Univ, Universidade Federal de São Paulo (UNIFESP), Chinese Univ Hong Kong, Univ Autonoma Baja California, GlaxoSmithKline, Ege Univ, Korea Univ, Chang Gung Mem Hosp, Univ Western Australia, and Ege Üniversitesi
- Subjects
Spirometry ,medicine.medical_specialty ,Quality Assurance, Health Care ,Exacerbation ,International Journal of Chronic Obstructive Pulmonary Disease ,Physicians, Primary Care ,Pulmonary Disease, Chronic Obstructive ,Quality of life (healthcare) ,General Practitioners ,Surveys and Questionnaires ,Health care ,medicine ,Humans ,COPD ,survey ,Europe, Eastern ,guidelines ,Practice Patterns, Physicians' ,Disease management (health) ,Original Research ,Primary Health Care ,medicine.diagnostic_test ,Asia, Eastern ,business.industry ,questionnaire ,Primary care physician ,Disease Management ,Physicians, Family ,General Medicine ,medicine.disease ,Latin America ,Health Care Surveys ,Family medicine ,Africa ,Needs assessment ,Clinical Competence ,Guideline Adherence ,business ,Needs Assessment - Abstract
WOS: 000319053100028, PubMed ID: 22563246, Chronic obstructive pulmonary disease (COPD) is a multicomponent disorder that leads to substantial disability, impaired quality of life, and increased mortality. Although the majority of COPD patients are first diagnosed and treated in primary care practices, there is comparatively little information on the management of COPD patients in primary care. A web-based pilot survey was conducted to evaluate the primary care physician's, or general practitioner's (GP's), knowledge, understanding, and management of COPD in twelve territories across the Asia-Pacific region, Africa, eastern Europe, and Latin America, using a 10-minute questionnaire comprising 20 questions and translated into the native language of each participating territory. The questionnaire was administered to a total of 600 GPs (50 from each territory) involved in the management of COPD patients and all data were collated and analyzed by an independent health care research consultant. This survey demonstrated that the GPs' understanding of COPD was variable across the territories, with large numbers of GPs having very limited knowledge of COPD and its management. A consistent finding across all territories was the underutilization of spirometry (median 26%; range 10%-48%) and reliance on X-rays (median 14%; range 5%-22%) for COPD diagnosis, whereas overuse of blood tests (unspecified) was particularly high in Russia and South Africa. Similarly, there was considerable underrecognition of the importance of exacerbation history as an important factor of COPD and its initial management in most territories (median 4%; range 0%-22%). Management of COPD was well below guideline-recommended levels in most of the regions investigated. The findings of this survey suggest there is a need for more ongoing education and information, specifically directed towards GPs outside of Europe and North America, and that global COPD guidelines appear to have limited reach and application in most of the areas studied., GlaxoSmithKlineGlaxoSmithKline, The authors would like to thank GlaxoSmithKline for the financial support of the study and Dr Jagdish Devalia for assistance in the preparation and editing of this article.
- Published
- 2012
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