1. Long-lasting impact of perinatal dietary supplementation of omega 3 fatty acids on mevalonate pathway: potential role on neuron trophism in male offspring hippocampal formation
- Author
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Valentina Pallottini, Sara Schiavi, Claudia Tonini, Marco Segatto, Fabrizio Macca, Viviana Trezza, Tonini, C., Schiavi, S., Macca, F., Segatto, M., Trezza, V., and Pallottini, V.
- Subjects
Male ,0301 basic medicine ,Long lasting ,medicine.medical_specialty ,Offspring ,Mevalonic Acid ,Medicine (miscellaneous) ,Biology ,Hippocampal formation ,Hippocampus ,nerve growth factor ,omega 3 fatty acids ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Cholesterol ,hydroxy-methylglutaryl Coenzyme A reductase ,mevalonate pathway ,Pregnancy ,Internal medicine ,Fatty Acids, Omega-3 ,Nerve Growth Factor ,medicine ,Animals ,Dietary supplementation ,Cyclic AMP Response Element-Binding Protein ,Neurons ,030109 nutrition & dietetics ,Nutrition and Dietetics ,General Neuroscience ,General Medicine ,Rats ,Enzyme Activation ,medicine.anatomical_structure ,Nerve growth factor ,Endocrinology ,Animals, Newborn ,chemistry ,Dietary Supplements ,Female ,Hydroxymethylglutaryl CoA Reductases ,Neuron ,Mevalonate pathway ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Objective: We were aimed at evaluating the long-term impact of perinatal an omega-3 fatty acid-enriched diet on the mevalonate/cholesterol pathway in the brain of male offspring. Methods: Female rats were fed with standard or omega-3 fatty acid-enriched diet during pregnancy and lactation. Liver, brain and plasma were collected from infant, adolescent and adult male offspring for subsequent biochemical and morphological analyses. Results: The omega-3 enriched diet induced region-dependent changes of the 3-hydroxy 3-methylglutaryl Coenzyme A reductase in the brain and affected notably RhoA/CREB signaling and the nerve growth factor content in the hippocampus. Our data reveal a long-lasting impact of perinatal omega-3 fatty acid supplementation on hippocampal nerve growth factor levels mediated by reduced 3-hydroxy 3-methylglutaryl Coenzyme A reductase activation state and enhanced CREB signaling. Discussion: These data underline the importance of the perinatal omega-3 enriched diet for adult brain function and reveal a new pathway important for nerve growth factor regulation.
- Published
- 2020
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