1. The efficacy of fractional carbon dioxide (CO2) laser combined with terbinafine hydrochloride 1% cream for the treatment of onychomycosis
- Author
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Yang Xu, Juan Liu, Dan Luo, Bingrong Zhou, Di Wu, Jian Shi, He Huang, Felicia Permatasari, and Jin Li
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Co2 laser ,business.industry ,Terbinafine hydrochloride 1% cream ,030106 microbiology ,Topical antifungal ,Dermatology ,Fungal microscopy ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Topical agents ,Medicine ,Terbinafine ,Surgery ,Clinical efficacy ,business ,Adverse effect ,medicine.drug - Abstract
Background: Although systemic and topical antifungal agents are widely used to treat onychomycosis, oral medications can cause adverse effects and the efficacy of topical agents is not satisfying. Currently, laser treatment has been studied for its efficacy in the treatment of onychomycosis. Our study was aimed to evaluate the efficacy of fractional carbon dioxide (CO2) laser treatment combined with terbinafine cream for 6 months in the treatment of onychomycosis and to analyze the influencing factors. Methods: A total of 30 participants (124 nails) with clinical and mycological diagnosis of onychomycosis received fractional CO2 laser treatment at 2-week interval combined with terbinafine cream once daily for 6 months. The clinical efficacy rate (CER) was assessed from the percentage of fully normal-appearing nails or nails with ≤5% abnormal appearance, and the mycological clearance rate (MCR) was assessed from the percentage of nails with negative fungal microscopy. Results: The CER was evaluated...
- Published
- 2017