1. Immunointervention in Type 1 (Insulin-Dependent) Mellitus Diabetes
- Author
-
Guido Somers and Bart Keymeulen
- Subjects
Type 1 diabetes ,Nicotinamide ,business.industry ,Azathioprine ,General Medicine ,Disease ,medicine.disease ,medicine.disease_cause ,Autoimmunity ,Clinical trial ,chemistry.chemical_compound ,chemistry ,Cyclosporin a ,Insulin dependent diabetes ,Immunology ,medicine ,business ,medicine.drug - Abstract
The hitherto identified hallmarks of the autoimmune aspects in Type 1 diabetes are reviewed. Their implication in the disclosure of the pre-clinical phase of the disease is put forward. The possible delineation of this pre-diabetic phase can lead to an early immunotherapeutic approach. The effect of immunomodulation by agents such as azathioprine, cyclosporin A and nicotinamide in newly diagnosed diabetes and the use of some of these drugs in clinical trials on pre-diabetic individuals are discussed.
- Published
- 1993
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