1. IKK connects autophagy to major stress pathways
- Author
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Amena BenYounès, Alfredo Criollo, Maximilien Tailler, Shensi Shen, Lorenzo Galluzzi, Alain Israël, Véronique Baud, Nicolas F. Delahaye, Laura Senovilla, Gérard Pierron, Hélène Authier, Maria Chiara Maiuri, Eugenia Morselli, Guido Kroemer, Laurence Zitvogel, Oliver Kepp, Francis Harper, Daniela De Stefano, Antoine Tesniere, Ilio Vitale, Ezgi Tasdemir, Sergio Lavandero, Criollo, A, Senovilla, L, Authier, H, Maiuri, MARIA CHIARA, Morselli, E, Vitale, I, Kepp, O, Tasdemir, E, Galluzzi, L, Shen, S, Tailler, M, Delahaye, N, Tesniere, A, DE STEFANO, Daniela, Younes, Ab, Harper, F, Pierron, G, Lavandero, S, Zitvogel, L, Israel, A, Baud, V, and Kroemer, G.
- Subjects
Autophagy ,AMPK ,Context (language use) ,Cell Biology ,IκB kinase ,Biology ,Models, Biological ,I-kappa B Kinase ,Cell biology ,Stress, Physiological ,Cytoplasm ,Animals ,Humans ,Molecular Biology ,Transcription factor ,PI3K/AKT/mTOR pathway ,Signal Transduction - Abstract
Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFkappaB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IkappaB kinase) complex, which is critical for the stress-elicited activation of NFkappaB, is sufficient to promote autophagy independent of NFkappaB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers.
- Published
- 2010