1. Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders
- Author
-
Junyan Feng, Fei-Yong Jia, Hong-Hua Li, Zhi-Da Xu, Han-Yu Dong, and Bing Wang
- Subjects
Vitamin ,medicine.medical_specialty ,Tic disorder ,Phonic Tic ,business.industry ,medicine.disease ,Gastroenterology ,vitamin D deficiency ,030227 psychiatry ,03 medical and health sciences ,Motor tics ,chemistry.chemical_compound ,0302 clinical medicine ,chemistry ,Internal medicine ,mental disorders ,Severity of illness ,medicine ,Vitamin D and neurology ,Clinical Global Impression ,business ,030217 neurology & neurosurgery - Abstract
Purpose Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs. Patients and methods In total, 120 children with CTDs and 140 normal controls were enrolled in this study, with 36/120 of those in the CTD group receiving vitamin D3 treatment for 3 months. The Yale Global Tic Severity Scale (YGTSS) and Clinical Global Impression of Severity of Illness (CGI-SI) were, respectively, used to evaluate the tic severity. High-performance liquid chromatography and tandem mass spectrometry were used to measure serum 25(OH)D level. Results Those children with CTDs exhibited significantly lower 25(OH)D levels than did healthy controls, and these reduced 25(OH)D levels were linked to increasing severity of tic symptoms. After treatment with supplemental vitamin D3, serum 25(OH)D level and scores of YGTSS total, motor tics, phonic tics, total tic, impairment, and CGI-SI improved significantly in children with CTDs without any adverse reactions. Conclusion Supplementation vitamin D3, given its low cost and excellent safety, may be an effective means of improving symptoms in certain children with CTDs.
- Published
- 2019