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We aimed to evaluate clinicopathological data in high-risk early-stage cervical cancer and to define the prognostic factors determining the oncological outcomes. This retrospective study included 158 patients with stage IB-IIA cervical cancer who underwent radical hysterectomy plus lymph node dissection. Each patient had at least one high-risk factor. The median tumour diameter of the study group was 30 mm (range, 6-80). Seventy-five (47.5%) patients had parametrial invasion, 32 (20.3%) had positive surgical margins, and 108 (68.4%) had lymph node metastasis. The median duration of follow-up was 42 months (range, 1-228). During this period, 28 patients developed recurrence, and the recurrent disease occurred in a distant area in 18 patients. Five-year disease-free survival was 77.5%, and five-year disease-specific survival was 85%. In multivariate analysis, adjuvant radiotherapy was identified as an independent prognostic factor for recurrence and death. The recurrence (Odds ratio: 10.139, 95% CI: 1.477-69.590

Intimate partner violence is a global social and public health concern with multifaceted biopsychosocial, economic and legal repercussions. Depression, anxiety, and stress are high risk factors in ...

Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression.This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations.The study included 75 healthy subjects and 75 patients with NAFLD. Different genotypes of IL-1A (I/D) gene polymorphism were determined by PCR-PAGE technique, serum IL-1A level and other biochemical parameters were measured.The major D allele was significantly associated with NAFLD patients (p = .002). DD genotype showed a significant increase in BMI and decrease in HDL-C. Also serum IL-1A was significantly correlated with the DD genotype. Serum IL-1A showed a significant positive correlation with BMI, triglycerides, total cholesterol, LDL-C, VLDL-C and FBG, and a significant negative correlation with HDL-C.Major D allele of IL-1A (I/D) gene polymorphism is associated with NAFLD in the Egyptian population.

This article reviews the frequency of suicide, compares and contrasts suicide prediction to suicide assessment and provides a succinct overview of suicide high risk factors that mental health pract...

The number of discharges (63,303) from a university-affiliated medical center in Israel were reviewed. Eight percent of cases in three departments received social work services. Patients experiencing inappropriate hospital stay (discharge delay) and who received social work services were characterized and compared with social work clients not experiencing delay. Discharge delay patients differed from other social work clients on key sociodemographic variables. Patients admitted because of “injury” were significantly more likely to experience delay than patients admitted because of “illness.” “Waiting for community/institutional resources” was the most common reason for delay and discharge to an institutional setting increased the likelihood of delayed discharge. High risk factors were department-specific and should be studied in context. Results suggested the limited but positive impact of hospital-community collaborative strategies in reducing the incidence of delay over time.

Through an examination of the literature and a review of industrial case studies, a qualitative model is developed of the risks associated with implementing information technology (IT) projects. When this approach was applied to case studies drawn from academia and from companies in the manufacturing and service industries, potential high risk factors were identified and classified. Ongoing research seeks to develop an intelligent risk analyzer that incorporates this qualitative model and industry best practices to give IT project managers significant decision support in the area of risk management by enabling them to match system development strategies with project complexity.

This study analyzed the differences in posture and fine motor control between at-risk preterm and full-term infants. On a qualitative measure with a sample of 65 full-term and 25 preterm infants, the full-term infants scored significantly higher in all aspects of posture and fine motor control than the preterm infants of the same adjusted ages. When the preterm infants were further categorized by number of medical risk factors, the postural differences existed only in preterm infants with high risk factors. All preterm infants (those with high and low risk factors) demonstrated less fine motor control when compared to full-term. These results have implicated regarding the qualitative differences that may be observed in preterm infants during the first months of life.

To improve the medical care access of the poorest women and newborns, South Carolina began a High Risk Channeling Project since April 1986. The Project directs physicians to screen all Medicaid-eligible pregnant women and newborns for specified clinical high risk factors. High risk patients are channeled to designated clinics for prenatal and newborn care. Channeled pregnant women are directed to deliver their babies at regional referral hospitals. For the first two years of the Project, about two-thirds of pregnancies and 60% of newborns were actually screened. Channeled women were much more likely than the non-channeled to deliver at higher level hospitals. In counties where relatively few women were channeled, the rate of prematurity among Medicaid newborns was significantly higher than in other counties.

This is a part of a prospective follow‐up study of 1196 newborn infants with certain neonatal high risk factors. About one third of the group consisted of children with neonatal hyperbilirubinaemia; they had a serum bilirubin value > 340 mmol/l or had had blood exchange transfusions. They were born in 1971‐74 at the State Maternity Hospital, Helsinki. Thirteen children were severely handicapped and excluded from the series and 54 were not traced or parents refused to bring them to the check‐up. 314 children were examined at the age of five and/or nine years. The control series comprised 72 children. The results indicated that the children with neonatal hyperbilirubinaemia managed less well in neurological and psychological tests than the control group, they had poorer school marks and more often attended special classes for somatic and psychic handicaps or for the mentally retarded. Their results were, nevertheless, often better than those for the rest of the risk group.