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Following the amalgamation of the Siberian and North China Cratons, NE China, as part of the Central Asian Orogenic Belt (CAOB), underwent Late Mesozoic lithospheric extension that was associated w...

The relationship among magmatism, large-scale metallogenesis of Southeast China, and subduction of the Pacific plate has long been debated. The lower Yangtze River belt (LYRB) in the northeastern edge of Southeast China is characterized by intense late Mesozoic magmatism and associated polymetallic mineralization such as copper, gold, iron, tungsten, molybdenum, etc. The copper-related adakitic rocks (148–130 Ma) in this belt are the oldest episode of magmatism and intruded as small intermediate-acid intrusive bodies. The Huayuangong granitoids (HYG), located in the southern part of this belt, however, are copper-barren. Three granitoid samples from this pluton give zircon U–Pb ages of 126.4 ± 1.6 Ma, 125.9 ± 1.9 Ma, and 126.2 ± 1.2 Ma, respectively. The HYG has A-type affinity with metaluminous to weakly peraluminous, high FeOT/(FeOT+MgO) ratios, and high Zr+Nb+Ce+Yb contents. Meanwhile, 10 late Mesozoic mafic samples from the LYRB exhibit similar trace element characteristics to those of ‘contin...

Purpose: Dysthyroid optic neuropathy (DON) is the most severe condition in thyroid eye disease (TED); however, no study has been conducted to assess quality of life in these patients to date. The aim of this study was to evaluate vision-related quality of life in TED patients with DON using a Chinese version of the 25-item National Eye Institute Visual Function Questionnaire (CHI-VFQ-25). Methods: The CHI-VFQ-25 scores were compared for 23 TED patients with DON and 13 TED patients without DON. The correlations between the clinical characteristics and subscale scores on the CHI-VFQ-25 and the floor and ceiling effects of the CHI-VFQ-25 were also assessed. Results: Patients with DON scored significantly lower than patients without DON on the CHI-VFQ-25 (composite score: 54 versus 77, respectively, p = 0.001). Many subscales were significantly correlated with the severity and activity of the disease (p50.05). In patients with DON, no floor effects were found, and ceiling effects were only observed for Color vision, Peripheral vision and Social function. Role limitations and Mental health were the lowest scores in all the subscales. Conclusions: The current study showed that vision-related quality of life tended to be more severely impaired in TED patients with DON than in patients without DON. The CHI-VFQ-25 may be a promising tool to estimate the benefits of interventions in patients with DON.

The eastern Qinling belt is characterized by widespread Mesozoic post-orogenic magmatism and abundant Mo–(Au–Ag) polymetallic mineralization. Most Mo deposits in this belt are genetically related to Mesozoic granitoids. The tectonic context of this close spatial and temporal relationship is still debated. This study reports U–Pb ages and Hf isotopic composition of zircons, major and trace element and Sr–Nd–Pb isotopic composition of the Donggou granite porphyry, host rock to one of the important Mesozoic Mo deposits in this orogen. Based on geochemical results, the Donggou granite porphyry is a silica-supersaturated, high-K metaluminous A-type granite showing enrichment in light REEs, depletion in middle REEs and significant negative Eu, Ba, Nb, Sr, P, and Ti anomalies. Negative initial ϵNd values of −17.0 to −13.2 for whole-rock and negative initial ϵHf values of −19.9 to −7.8 for zircon suggest that the magma was derived from a mixture of Archaean/Proterozoic crustal rocks and mantle-derived or newly ad...

Two polypyridine ruthenium(II) complexes, [Ru(dmp)2(MCMIP)]2+ (1) (MCMIP = 2-(6-methyl-3-chromonyl)imidazo[4,5-f][1,10]-phenanthroline, dmp = 2,9-dimethyl-1,10-phenanthroline) and [Ru(dmb)2(MCMIP)]2+ (2) (dmb = 4,4′-dimethyl-2,2′-bipyridine), have been synthesized and characterized by elemental analysis, ES-MS and 1H NMR. The DNA-binding behaviors of these complexes were investigated by electronic absorption titration, fluorescence spectroscopy, viscosity measurements and thermal denaturation. The results show that 1 and 2 effectively bind to CT-DNA; the DNA-binding affinities are closely related to the ancillary ligand.

We describe a 10-year-old Chinese girl with blurred vision in her left eye over a month and an optic nerve “mass” of her left orbit shown on computed tomography. The patient was initially misdiagnosed as having a retrobulbar tumour. However, detailed fundus examination showed a very deep excavation surrounding the disc and magnetic resonance imaging revealed excavation of the posterior wall connected to the vitreous cavity. These findings suggested a diagnosis of peripapillary staphyloma. The reasons for the misdiagnosis are discussed.

We read with great interest the review article by Dr. Woung and associates.1 They reviewed the recent important studies on optic neuritis in Asia, and compared them with those in Western countries. Their article included the studies addressed in Taiwan, Japan, India, and Singapore. However, several important studies in mainland China had not been included. We would like to review them in this letter. Almost all the studies in Asia that were published in the English language investigated unilateral and bilateral acute optic neuritis (AON) simultaneously. In the Optic Neuritis Treatment Trial (ONTT), however, the investigators only recruited the patients with unilateral AON.2 According to the literature, the proportion of bilateral AON in Asia is 25–33%.3 It is unsuitable to mix bilateral and unilateral AON, and to compare them with ONTT due to the significantly different features of bilateral and unilateral AON. In mainland China, Dr. Du described unilateral and bilateral AON separately,3,4 and found that bilateral AON has some clinical differences from unilateral AON, including a higher prevalence of male cases and disc swelling, and more severe initial visual loss, but quicker visual recovery.3 In our experiences, considerable Chinese patients with AON have a very poor visual prognosis.4,5 Dr. Lai and associates studied this subgroup of Chinese patients, and found that these patients have a high positive rate of anti-aquaporin-4 antibody (neuromyelitis optica immunoglobulin G),6,7 which is a highly sensitive and specific antibody in patients with neuromyelitis optica. For this reason, Dr. Lai’s studies had partly demonstrated the hypotheses proposed by Dr. Du, that a proportion of Chinese patients with AON might develop neuromyelitis optica during long-term follow-up, or might be a forme fruste of neuromyelitis optica.8 Although most knowledge of clinical aspects of optic neuritis is from the Optic Neuritis Treatment Trial, some cases in the Optic Neuritis Treatment Trial also had poor visual recovery, and the reason remains unclear, which is similar to the situation clinicians in China have to face almost every day. We hope our colleagues in the world keep an eye on optic neuritis studies in mainland China.