1. Murine Leukemia Virus Long Terminal Repeat Sequences Can Enhance Gene Activity in a Cell-Type-Specific Manner
- Author
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K Chaffin, B Davison, and F K Yoshimura
- Subjects
viruses ,Cell ,Virus ,Mice ,biology.animal ,hemic and lymphatic diseases ,Murine leukemia virus ,Genes, Regulator ,medicine ,Animals ,Lymphocytes ,Mink ,Enhancer ,Molecular Biology ,Cells, Cultured ,Repetitive Sequences, Nucleic Acid ,Regulation of gene expression ,biology ,Base Sequence ,Cell Biology ,Fibroblasts ,biology.organism_classification ,Cell Transformation, Viral ,Virology ,Molecular biology ,Long terminal repeat ,Leukemia Virus, Murine ,Transformation (genetics) ,medicine.anatomical_structure ,Enhancer Elements, Genetic ,Gene Expression Regulation ,Research Article - Abstract
We tested the ability of sequences in the long terminal repeat (LTR) of a mink cell focus-forming (MCF) murine leukemia virus to function as an enhancer in a cell-type-specific manner. In a stable transformation assay, the MCF or Akv LTR and the simian virus 40 enhancer had similar activities in murine fibroblasts. In contrast, the MCF LTR had a significantly greater activity in murine T lymphoid cells than did either the simian virus 40 enhancer or the Akv LTR.
- Published
- 1985
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