1. Surgical Trauma-induced CCL2 Upregulation Mediates Lung Cancer Progression by Promoting Treg Recruitment in Mice and Patients
- Author
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Kaibin Zhu, Xiaoyu Zheng, Yubo Yan, Jinfeng Ning, Jianlong Bu, Jian Zhang, Xidong Zhu, Shidong Xu, Su Zhao, and Mengfeng Liu
- Subjects
Male ,Cancer Research ,Lung Neoplasms ,medicine.medical_treatment ,CCL2 ,T-Lymphocytes, Regulatory ,Mice ,Downregulation and upregulation ,Carcinoma, Non-Small-Cell Lung ,Surgical removal ,medicine ,Animals ,Humans ,Lung cancer ,Chemokine CCL2 ,Aged ,business.industry ,Cancer ,Immunosuppression ,General Medicine ,Middle Aged ,medicine.disease ,Up-Regulation ,Gene Expression Regulation, Neoplastic ,Thoracotomy ,Oncology ,A549 Cells ,Case-Control Studies ,Disease Progression ,Cancer research ,Female ,business ,Neoplasm Transplantation - Abstract
Surgical removal of the tumor is currently the first-line treatment for lung cancer, but the procedure may accelerate cancer progression through immunosuppression. However, whether CCL2 (C-C motif chemokine ligand 2) enhances cancer progression by affecting regulatory T cells (Tregs) remains unknown. We found that the volume and weight of tumors were larger in the surgical trauma group than in the control group. CCL2 expression and Treg abundance were increased in tumor tissues after surgical trauma, and CCL2 expression was positively associated with Treg abundance. These results demonstrated that surgical trauma contributes to lung cancer progression by increasing CCL2 expression, thus promoting Treg recruitment.
- Published
- 2021
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