1. Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice
- Author
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Pavel Mikuška, Ivan Míšek, Marcela Buchtová, Zuzana Nováková, Aleš Hampl, Jana Dumková, Z. Večeřa, Bohumil Dočekal, Jana Lebedová, Lucie Bláhová, and Klára Hilscherová
- Subjects
Male ,010504 meteorology & atmospheric sciences ,Biomedical Engineering ,Nanoparticle ,010501 environmental sciences ,Kidney ,Toxicology ,medicine.disease_cause ,01 natural sciences ,Road transport ,Mice ,Administration, Inhalation ,Tissue damage ,medicine ,Animals ,Tissue Distribution ,Lung ,0105 earth and related environmental sciences ,Inhalation exposure ,Inhalation Exposure ,Chemistry ,Brain ,Oxides ,Glutathione ,3. Good health ,Lead ,Liver ,Environmental chemistry ,Nanoparticles ,Lipid Peroxidation ,Oxidative stress - Abstract
Lead nanoparticles (NPs) are released into air from metal processing, road transport or combustion processes. Inhalation exposure is therefore very likely to occur. However, even though the effects of bulk lead are well known, there is limited knowledge regarding impact of Pb NPs inhalation. This study focused on acute and subchronic exposures to lead oxide nanoparticles (PbO NPs). Mice were exposed to PbO NPs in whole body inhalation chambers for 4-72 h in acute experiment (4.05 × 10
- Published
- 2018
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