1. A new nitrogen-containing iridoid glycoside from lonicera macranthoides
- Author
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Dan-Feng Shi, Ling-Xian Liu, Yu-Dan Mei, Yang Yu, Hai-Bo Li, Xin-Sheng Yao, and Da-Bo Pan
- Subjects
Iridoid Glycosides ,chemistry.chemical_classification ,Traditional medicine ,Iridoid ,010405 organic chemistry ,medicine.drug_class ,Organic Chemistry ,Glycoside ,Plant Science ,01 natural sciences ,Biochemistry ,Anti-inflammatory ,0104 chemical sciences ,Analytical Chemistry ,Lonicera macranthoides ,010404 medicinal & biomolecular chemistry ,chemistry ,medicine - Abstract
A new nitrogen-containing iridoid glycoside, named (7 R,3���R)-lonijapospiroside A (1), together with thirteen known iridoid glycosides, were isolated from the flower buds of Lonicera macranthoides. The structures of these compounds were established on the basis of spectroscopic analyses. Among them, compounds 1-4 are four diastereoisomers, and their absolute configurations were accurately established by the NOE spectra as well as comparison of their experimental and calculated ECD spectra. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on NO, IL-6, and TNF-�� production in LPS stimulated RAW 264.7 macrophages. Compound 14 exhibited anti-inflammatory activities by inhibiting IL-6 with an IC50 value of 54.70 ��M, comparable to that of the positive control (hydrocortisone, IC50: 62.6 �� 1.7 ��M).
- Published
- 2020
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