1. Benefit of tianeptine and morphine in a transgenic model of familial amyotrophic lateral sclerosis
- Author
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Gérard Besson, Marc Savasta, M. Chritin, Département de neurologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Dynamique des Reseaux Neuronaux, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Collaboration, and Savasta, Marc
- Subjects
Male ,MESH: Thiazepines ,Thiazepines ,Disease ,Antidepressive Agents, Tricyclic ,Pharmacology ,MESH: Analgesics, Opioid ,medicine.disease_cause ,Transgenic Model ,Mice ,0302 clinical medicine ,MESH: Animals ,Tianeptine ,Amyotrophic lateral sclerosis ,MESH: Amyotrophic Lateral Sclerosis ,MESH: Superoxide Dismutase ,MESH: Treatment Outcome ,0303 health sciences ,Mutation ,Morphine ,General Medicine ,MESH: Recovery of Function ,3. Good health ,Analgesics, Opioid ,Survival Rate ,Drug Combinations ,Treatment Outcome ,Neurology ,Anesthesia ,Injections, Intraperitoneal ,MESH: Injections, Intraperitoneal ,medicine.drug ,Genetically modified mouse ,MESH: Survival Rate ,MESH: Mice, Transgenic ,SOD1 ,Mice, Transgenic ,03 medical and health sciences ,medicine ,Animals ,MESH: Mice ,Pathological ,030304 developmental biology ,MESH: Drug Combinations ,Superoxide Dismutase ,business.industry ,Amyotrophic Lateral Sclerosis ,Recovery of Function ,medicine.disease ,MESH: Male ,MESH: Antidepressive Agents, Tricyclic ,Disease Models, Animal ,MESH: Morphine ,Neurology (clinical) ,MESH: Disease Models, Animal ,business ,030217 neurology & neurosurgery - Abstract
International audience; The familial form of amyotrophic lateral sclerosis (FALS) has been linked in some cases to dominant mutations in the gene encoding the Cu/Zn superoxide dismutase (SOD1) mutation. Transgenic mice bearing the G93A SOD1 mutation develop clinical symptoms and pathological features similar to those described in the human disease and represent a good model to explore the potential benefit of therapeutic agents. Using this animal model, we tested the efficacy of morphine and tianeptine treatments, separately and in association, on both disease progression and survival. Acute injection of either of them, administered daily and before the onset of the disease, significantly prolonged the survival of the transgenic mice.
- Published
- 2006
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