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This article explores the work of three contemporary Northern Irish poets, Leontia Flynn, Sinead Morrissey and Alan Gillis, asking how this work relates to fragility as experienced in Northern Ireland. Is there, within this poetry, a fostering of hope with respect to Northern Ireland's fragile future? Does a new generation of poets look for continuity with the past or does it strike out on a new path? The first part of the article provides a brief introduction to the ‘first-generation peace poets’, and also gives an overview of the ways in which Northern Irish poetry has been criticized in recent decades. It then suggests that this literature might be read through the lens of the elegiac tradition, as well as by exploring the ‘post-theory’ approach of new aestheticism. The second part comprises a series of close readings, with particular emphasis on poems about Belfast, and other poems that deal with themes of loss.

Vps1 is the yeast dynamin-like protein that functions during several membrane trafficking events including traffic from Golgi to vacuole, endosomal recycling and endocytosis. Vps1 can also function in peroxisomal fission indicating that its ability to drive membrane fission is relatively promiscuous. It has been of interest therefore that several mutations have been identified in Vps1 that only disrupt its endocytic function. Most recently, disruption of the interaction with actin through mutation of residues in one of the central stalk α helices (RR457,458 EE) has been shown to disrupt endocytosis and cause an accumulation of highly elongated invaginations in cells. This data supports the idea that an interaction between Vps1 and actin is important to drive the scission stage in endocytosis. Another Vps1 mutant generated in the study was vps1 E461K. Here we show data demonstrating that the E461K mutation also disrupts endocytosis but at an early stage, resulting in inhibition of the invagination step itself.

Most judicial practitioners throughout the world today would agree that criminal investigations relating to fraud and corruption are becoming more complex and multi‐national. The globalization of f...