1. microRNA-21: a key modulator in oncogenic viral infections
- Author
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Mengting Cai, Yong’e Zhang, Yadong Zheng, Guitian He, Juntao Ding, William C. Cho, and Jing Yang
- Subjects
viruses ,Review ,Biology ,Virus Replication ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Downregulation and upregulation ,Neoplasms ,microRNA ,medicine ,Animals ,Humans ,Molecular Biology ,030304 developmental biology ,0303 health sciences ,RNA ,Cancer ,Cell Biology ,medicine.disease ,Virology ,Oncolytic virus ,MicroRNAs ,Tumor Virus Infections ,Viral replication ,030220 oncology & carcinogenesis ,Host-Pathogen Interactions ,Oncogenic Viruses ,Oncovirus - Abstract
Oncogenic viruses are associated with approximately 15% of human cancers. In viral infections, microRNAs play an important role in host-pathogen interactions. miR-21 is a highly conserved non-coding RNA that not only regulates the development of oncogenic viral diseases, but also responds to the regulation of intracellular signal pathways. Oncogenic viruses, including HBV, HCV, HPV, and EBV, co-evolve with their hosts and cause persistent infections. The upregulation of host miR-21 manipulates key cellular pathways to evade host immune responses and then promote viral replication. Thus, a better understanding of the role of miR-21 in viral infections may help us to develop effective genetically-engineered oncolytic virus-based therapies against cancer.
- Published
- 2021
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