Search

Aliphatic hydroxamic acids (HA) with varying numbers of carbon atoms, C2, C6, C8, C10, C12 and C17, and corresponding Fe(II), Fe(III), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and characterized by various methods, including structural determination by single crystal X-ray diffraction and theoretical calculations. The biological activities of HA and their complexes have been assessed on a panel of pathogens, including eight bacteria strains and one fungus. The C12 aliphatic HA displayed the lowest minimum inhibitory concentrations (MIC) towards several microbial strains and a selective antifungal activity. This antifungal selectivity was further improved considering the Ni(II), Cu(II) and Zn(II) complexes of C12 HA showed higher IC50 values, thus less impact on the SiHa human cell line viability. This work warrants further investigation to understand the underlying mechanism of action and potential biological applications of HA and the derived metal complexes.

Les spectres RMN-13 C de quelques derives du propanol substitue en 1,3 ont ete etudies. Une attribution des signaux est propasee. Carbon-13 nuclear magnetic resonance spectra of some substituted 1, 3-propanols have been recorded and fully assigned.

A series of 5′-substituted-5′-deoxyadenosina derivatives, potential inhibitors of methyltransferases were synthesized and their carbon∼13 nuclear magnetic resonance spectra investigated.

Carbon-13 nuclear magnetic resonance spectra of some azonaphtalene sulfonates dyes have been recorded and the assignment of most signals is proposed.