1. Regulation of Leukaemia Associated Rho GEF (LARG/ARHGEF12)
- Author
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Neda Z Ghanem, Michelle L. Matter, and Joe W. Ramos
- Subjects
rho GTP-Binding Proteins ,Leukemia ,RHOA ,biology ,RHOB ,RhoC ,Cell migration ,Cell Biology ,GTPase ,Mini-Review ,Biochemistry ,Cell biology ,ras Proteins ,biology.protein ,Humans ,ras Guanine Nucleotide Exchange Factors ,Guanosine Triphosphate ,Guanine nucleotide exchange factor ,Ras superfamily ,Signal transduction ,rhoA GTP-Binding Protein ,rhoB GTP-Binding Protein ,Rho Guanine Nucleotide Exchange Factors - Abstract
The Ras homologous (Rho) protein family of GTPases (RhoA, RhoB and RhoC) are the members of the Ras superfamily and regulate cellular processes such as cell migration, proliferation, polarization, adhesion, gene transcription and cytoskeletal structure. Rho GTPases function as molecular switches that cycle between GTP-bound (active state) and GDP-bound (inactive state) forms. Leukaemia-associated RhoGEF (LARG) is a guanine nucleotide exchange factor (GEF) that activates RhoA subfamily GTPases by promoting the exchange of GDP for GTP. LARG is selective for RhoA subfamily GTPases and is an essential regulator of cell migration and invasion. Here, we describe the mechanisms by which LARG is regulated to facilitate the understanding of how LARG mediates functions like cell motility and to provide insight for better therapeutic targeting of these functions.
- Published
- 2021
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