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Two new flavonol glycosides, limocitrin 3-O-β-D-xylopyranosyl(1→2)-β-D-glucopyranoside (1) and limocitrin 3-O[2-O-β-D-xylopyranosyl-6-O-α-L-rhamnopyranosyl]-β-D-glucopyranoside (2), together with eight known analogs (3-10), were isolated from the fruits of Evodia rutaecarpa. Their structures were elucidated on the basis of spectroscopic analyses and chemical evidences. Meanwhile, Nrf2 inducing abilities of seven isolated compounds were evaluated, and compounds 1, 2, 6, 7, and 8 exhibited moderate effect on Nrf2.

A new flavonol glycoside, kaempferol-3-O-β-D-(2-O-E-p-coumaroyl)-glucopyranosyl-7-O-α-l-rhamnopyranoside (1), along with eleven known compounds including five flavonol glycosides (2-6), one phenolic glycoside (7), two megastigmane glycosides (8 and 9), two triterpenoids (10 and 11) and one alditol (12), was isolated from the aerial parts of Euonymus fortunei. Their structures were determined on the basis of spectroscopic analysis and chemical evidence. Compounds 2-4, 7, 8, and 10-12 were evaluated their antimicrobial activities against Ureaplasma urealyticumin vitro, but all tested compounds have no useful activities against Ureaplasma urealyticum.

The qualitative and quantitative analyses by HPLC and LC-DAD-MS/MS were conducted for the quality consistency evaluation of Compound Kushen Injection (CKI). For fingerprint analysis, 8 peaks were selected as the characteristic peaks in the HPLC chromatograms of 27 different batches of CKI samples and their similarities were more than 0.90, except the four samples. For the typical HPLC profile, peak identification was carried out by HPLC and LC-MS/MS analyses and as a result, 21 chromatographic peaks were identified or characterized based on the comparison of retention time and UV spectra with authentic compounds as well as by summarized MS fragmentation rules. Six of these identified compounds, including oxymatrine, oxysophocarpine, N-methylcytisine, matrine, sophocarpine, and trifolirhizin, were simultaneously determined and the results showed that the total amounts of six marker compounds were variable, to some extent, which was deduced to be related to the quality of the crude materials and the manufac...

A new steroidal saponin and three known saponins were isolated from the rhizomes of Dioscorea panthaica. Their structures were elucidated as 3-O-[α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl]-26-O-β-d-glucopyranosyl-20,22-seco-25(R)-furosta-5-ene-20,22-dione-3β,26-diol (1), pregnadienolone-3-O-β-chacotriside (2), pseudoprotodioscin (3), and dioscoreside D (4) mainly by NMR techniques and chemical methods. The inhibitory activities of the saponins against α-glucosidase were investigated, and compound 2 was found to exhibit potent activity with IC50 values of 0.04 ± 0.01 mM.