1. Modulation of Acute Phase Protein Synthesis in Cultured Rat Hepatocytes by Human Recombinant Hepatocyte Growth Factor
- Author
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Piotr Pierzchalski, Aleksander Koj, Toyohiro Takehara, and Toshikazu Nakamura
- Subjects
medicine.medical_treatment ,Clinical Biochemistry ,Dexamethasone ,Endocrinology ,medicine ,Animals ,Rats, Wistar ,Interleukin 6 ,Cells, Cultured ,Recombinant Hepatocyte Growth Factor ,Messenger RNA ,DNA synthesis ,biology ,Hepatocyte Growth Factor ,Interleukin-6 ,Chemistry ,Acute-phase protein ,Cell Biology ,Molecular biology ,Recombinant Proteins ,Rats ,Cytokine ,Liver ,biology.protein ,Hepatocyte growth factor ,Acute-Phase Proteins ,medicine.drug - Abstract
Human recombinant hepatocyte growth factor (HGF) added to primary cultures of rat hepatocytes stimulates synthesis of some acute phase proteins, especially alpha-2-macroglobulin. As indicated by changes in mRNA abundance HGF increases alpha-2-macroglobulin production at the pretranslational level. Interleukin-6, the main acute-phase cytokine, does not show synergy with HGF in enhancing synthesis of alpha-2-macroglobulin, and inhibits HGF-induced DNA-synthesis. On the other hand, dexamethasone potentiates the effects of HGF on synthesis of DNA and acute phase proteins by cultured rat hepatocytes.
- Published
- 1992
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