1. Primary Malignant Melanoma of the Esophagus
- Author
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Sabaratnam Sabanathan and Jibah Eng
- Subjects
Adult ,Male ,medicine.medical_specialty ,Esophageal Neoplasms ,medicine.medical_treatment ,Esophagus ,Recurrence ,Humans ,Medicine ,Surgical treatment ,Lentigo maligna melanoma ,Melanoma ,Survival rate ,Chemotherapy ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Surgery ,Radiation therapy ,medicine.anatomical_structure ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Rare disease - Abstract
Three cases of primary malignant melanoma of the oesophagus are presented and the literature is briefly reviewed. This rare disease affects predominantly males in the sixth decade of life or later and the clinical and radiologic features are indistinguishable from those of more common oesophageal carcinomas. The tumours are often polypoid, located mainly in the lower two-thirds of the esophagus, and their histologic features resemble those of lentigo maligna melanoma, but with more aggressive biologic behavior. Because of the potential for extensive intramucosal involvement, multicentricity and high local recurrence rate, surgical treatment requires radical excision with a much greater margin than for the common squamous cell carcinomas. Though the outlook is poor, surgery is the favoured treatment with palliative or curative intent, with a 5-year survival rate of 4.2%. Radiotherapy, chemotherapy and immunostimulation currently serve mainly as palliative or adjunctive measures.
- Published
- 1990
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