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Your search keyword '"Tsutomu Shichishima"' showing total 2 results
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2 results on '"Tsutomu Shichishima"'

1. Clinicopathological characteristics of malignant lymphoma in patients with hepatitis C virus infection in the Tohoku district in Eastern Japan

Author

Katsushi Tajima, Kenichi Ishizawa, Tsutomu Shichishima, Osamu Sasaki, Jugoh Itoh, Hideyoshi Noji, Naoto Takahashi, Tomoaki Akagi, Yuichi Kato, Masaharu Wano, Kazunori Murai, Yoji Ishida, and Hideo Harigae

Subjects
Adult, Male, Cancer Research, Lymphoma, Biopsy, Hepatitis C virus, Prevalence, medicine.disease_cause, Virus, 03 medical and health sciences, 0302 clinical medicine, Japan, Odds Ratio, medicine, Humans, Aged, Neoplasm Staging, Aged, 80 and over, medicine.diagnostic_test, biology, business.industry, virus diseases, Hematology, Hepatitis C, Middle Aged, medicine.disease, Virology, digestive system diseases, Oncology, Case-Control Studies, Population Surveillance, 030220 oncology & carcinogenesis, biology.protein, Female, 030211 gastroenterology & hepatology, Neoplasm Grading, Antibody, business, Viral hepatitis, Biomarkers
Abstract

Chronic hepatitis C virus (HCV) infection conditions are proposed to be an HCV syndrome of hepatic, extrahepatic or systemic disorders with malignancies such as a malignant lymphoma (ML).[1] HCV is...

Published
2016
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2. Case of a Child with Paroxysmal Nocturnal Hemoglobinuria Diagnosed by Flow Cytometry

Author

Junichi Nishimura, Teruo Kitani, Naoko Kinugawa, and Tsutomu Shichishima

Subjects
Male, Pathology, medicine.medical_specialty, Glycosylphosphatidylinositols, medicine.drug_class, Glycosylphosphatidylinositol, Ham test, Hemoglobinuria, Paroxysmal, Monoclonal antibody, Flow cytometry, Pathogenesis, chemistry.chemical_compound, CLs upper limits, hemic and lymphatic diseases, Humans, Medicine, Child, medicine.diagnostic_test, business.industry, Proteins, Negativity effect, Hematology, Flow Cytometry, medicine.disease, Oncology, chemistry, Pediatrics, Perinatology and Child Health, Immunology, Paroxysmal nocturnal hemoglobinuria, business
Abstract

A case of a child with paroxysmal nocturnal hemoglobinuria (PNH) is characterized by an increased sensitivity of the erythrocyte to hemolytic action of complement. The widely used Ham test may not always be reliable. Recently, a panel of monoclonal antibodies has become available to detect various glycosylphosphatidylinositol (GPI)-linked proteins by flow cytometry (FCM)1 and the deficiency of GPI-anchored proteins on the various kinds of cell membranes is implicated as the pathogenesis of PNH. We diagnosed a case of a child with PNH by FCM and complement lysis sensitivity (CLS) test, which showed the increased sensitivity of PNH erythrocytes to complement. His diagnosis was delayed because of Ham test negativity and rarity of PNH cases in children.

Published
1993
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