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Previous investigations on sentence production in English-speaking individuals with traumatic brain injury (TBI) have yielded mixed conclusions based on their findings. While some studies found comparable sentence complexity between speakers with TBI and control speakers, others reported more syntactic and lexical errors, reduced sentence complexity, and erroneous word order transpositions in the sentence production of speakers with TBI. These contradictory findings could possibly be due to the use of language measures that were less sensitive to subtle syntactic impairments among speakers with TBI. In this preliminary report, the language samples obtained from 11 Cantonese-speaking participants with mild-moderate TBI in Guangzhou, with a mean age of 37.6 and mean years of education of 10 years, and nine control speakers with a similar age range and education background were analyzed using in-depth linguistic-oriented frameworks adopted from pervious works in Cantonese. The results indicated that the TBI group produced more errors, different varieties of sentence types, and lower syntactic complexity in their sentence production compared with the control group. The findings suggested that the more refined and linguistic-oriented measures used in the present study were more sensitive in identifying the subtle syntactic impairments produced by the participants with TBI.

This study investigated the grapho-motor patterns used in writing Chinese characters. A Chinese patient, CSC, who demonstrated post-brain-injury mirror writing, was recruited. In Experiment 1, non-mirrored writing responses were obtained when CSC was instructed to copy asymmetrical non-verbal symbols and pictures. Resembling the patterns observed in a patient's writing reported in a previous study, it was hypothesized that CSC's mirror writing was a result of untransformed preserved grapho-motor patterns. In Experiments 2 and 3, CSC was further instructed to copy real Chinese characters, pseudo-characters with authentic radicals and logographemes (i.e., stroke clusters that frequently occur in radicals), and Hangul characters with stroke clusters resembling the shapes of authentic logographemes. The results showed that CSC demonstrated mirror writing only when authentic Chinese orthographic units were involved. Non-mirrored writing responses were obtained from stimuli without authentic Chinese orthographic units. In sum, CSC's performance supported the existence of grapho-motor patterns of Chinese orthographic units represented in the brain. Theoretical implications were discussed.

Drug-drug interactions (DDIs) can result in serious consequences, including death. Existing methods for identifying potential DDIs in post-marketing surveillance primarily rely on spontaneous reports. These methods suffer from severe underreporting, incompleteness, and various bias. The aim of this study was to more effectively screen potential DDIs using patient electronic data and temporal association mining techniques.We focus on discovery of potential DDIs by analyzing the temporal relationships between the concurrent use of two drugs of interest and the occurrences of various symptoms. We introduced innovative functional temporal association rules where the degree of temporal association between two events within a patient case was defined by a function.Preliminary test results on two drug pairs (i.e.,benazepril, losartanandbenazepril, insulin) were classified into 260 clinically meaningful categories. These categories were evaluated by physicians and the results exhibited that all the potential DDIs were confined to top 20 of the 260 outcomes.Our methodology can be used to dramatically reduce a long list of association rules to a manageable list for further analysis and investigation by drug safety professionals.

This study investigated the contributions of different cognitive measures in predicting the three types of Chinese characters: regular phonetic compounds, irregular phonetic compounds and non-phonetic compounds. A total of 246 Grade 3 children (mean age = 8.63 yrs) were tested using a bunch of tasks including phonological processing, orthographic processing, morphological processing, rapid automatised naming and Chinese character naming. Results showed that advanced phonological processing skills contributed largely to regular phonetic compounds naming while other cognitive measures predict the naming of the other two types of characters. The results imply that the skills underlying the learning of regular phonetic compounds are different from that of irregular phonetic compounds and non-phonetic compounds, which are similar. Data from three poor readers whose performances pattern on naming different types of Chinese characters agreed with the pattern predicted by their performances in different cognitive tasks provide further support to the claim. Theoretical and pedagogical implications were discussed.

The current study investigated the development of morphemic processing in reading Chinese compound words. A total of 14 grade 2 children and 17 grade 6 children were recruited. A word-naming task and a character- naming task were conducted. Significant boundedness effects were observed in both word and character-naming tasks in grade 2. In contrast, significant boundedness effect was only found in character naming but not in word naming in grade 6. Results revealed that the functional size of morphemes that beginning readers can manipulate progresses from large to small grain size. This developmental pattern provides supplementary information to the psycholinguistic grain size theory (Ziegler & Goswami, 2005) to better explain reading development of Chinese. Educational and clinical implications were also discussed.

The influence of feed-forward consistency (FFC) (i.e., the consistency of mapping from the orthographic form to the pronunciation of the whole character) on character recognition and reading aloud ...

Cytokine transforming growth factor (TGF) is involved in regulation of tissue repair after injury. More recently, TGF-beta1 codon 10 gene polymorphism has been shown to be associated with circulating TGF-beta levels. We tested whether TGF-beta1 genotype polymorphism was predictive of renal allograft function decline.The study population consisted of 129 consecutive cadaveric or living related renal transplant recipients at our center between 1985 and 2001. The recipient TGF-beta1 genotype polymorphism was determined from peripheral blood leucocytes DNA. The primary endpoint was rate of glomerular filtration rate decline between the first year and the third year of transplant.Baseline glomerular filtration rate as estimated by MDRD study equation at 1 year measured 50+/-17 mL/min/1.73 m2. At the end of the 3-year follow-up period, 52 patients (40%) experienced biopsy-confirmed acute rejections. Frequency and severity of allograft rejection did not differ with TGF-beta genotypes. However, the decline in glomerular filtration rate was significantly greater in Leu/Leu (TT) than Leu/Pro (CT) recipients, 6.3+/-16.9 mL/min/1.73 m2 versus 0.1+/-10.2 mL/min/1.73 m2, p=0.04.Our results demonstrate that recipient TGF-beta1 codon 10 Leu/Leu homozygosity is a potential risk factor of kidney allograft function decline.

Normal Hong Kong schoolchildren readers from grades 1, 2 and 3 were involved in this experiment to find out at which grade the sub-character processing is employed to memorize newly learned Chinese characters. Subjects were required to work on a delayed-recall task with pseudo-characters constructed using different radical frequencies controlled across grades. Prior to the recall, verbal and visual intervening tasks were inserted to determine the use of phonological and visual memories in memorizing radicals with different frequencies. A significant frequency effect was found in the second graders but not in the first graders. Results suggested that subcharacter processing to memorize newly learned Chinese characters developed in the children starting from the second grade. The second graders' performances on high frequency radicals were affected by both verbal and visual intervening tasks, but their performances in low frequency radicals were affected more by visual intervening tasks than by verb...

Broiler chickens were raised on commercial wood shavings containing 134 p.p.m. pentachlorophenol and on control litter consisting of corn-cob chips. Initial analysis of the wood-shaving litter showed the presence of hepta-, octa- and nonachlorinated diphenyl ethers, octa- and nonachlorinated 2-phenoxyphenols, and hepta- and octachlorinated dibenzodioxins. Analysis of liver, fat, and muscle tissue after nine weeks indicated the assimilation of these compounds with pentachlorophenol being present in the highest concentration. Chlorinated diphenyl ethers were detectable only in fat, while octa- and nonachlorinated 2-phenoxyphenols were found in all three tissues examined. While liver and fat contained hepta- and octachlorinated dibenzodioxins, no hexachlorinated congener was detected nor were significant amounts of dioxin found in muscle tissue. Although gross pathological examination of the birds did not indicate abnormalities, a mixed type of hepatic enzyme induction was observed in those birds raised on wood shavings.

A mixture of 14 polychlorinated biphenyl (PCB) isomers of various congeners, representing approximately 70% of all human milk PCBs reported in the literature, was made up to identify and approximate their residues in human milk. Individual isomer levels varied from 5 to 103 nanograms per gram of milkfat with the 2,2′,4,4′,5,5′-hexachlorobiphenyl isomer as the major PCB contaminant of human milk. PCB isomer numbers 74, 118, 153, 138 and 180 made up approximately 75% of all PCBs as measured by this mixture. There was close agreement of total PCB isomer content in breast milk between electron capture gas chromatography and gas chromatographic mass spectrometry determinations. A major interference was encountered however for PCB isomer no. 52, whose residue level in the breast milk was approximately 3 x higher by gas liquid chromatography than by mass spectrometry.