1. Transcription and splicing
- Author
-
Yehuda Brody and Yaron Shav-Tal
- Subjects
Transcription, Genetic ,RNA Splicing ,Alternative splicing ,Intron ,Exonic splicing enhancer ,Biology ,Ribonucleoproteins, Small Nuclear ,Bioinformatics ,Biochemistry ,Cell biology ,Splicing factor ,Transcription (biology) ,Cell Line, Tumor ,RNA, Small Nuclear ,RNA splicing ,Genetics ,Humans ,RNA Polymerase II ,RNA, Messenger ,Point-of-View ,Gene ,Biotechnology ,Ribonucleoprotein - Abstract
Splicing can occur co-transcriptionally. What happens when the splicing reaction lags after the completed transcriptional process? We found that elongation rates are independent of ongoing splicing on the examined genes and suggest that when transcription has completed but splicing has not, the splicing machinery is retained at the site of transcription, independently of the polymerase.
- Published
- 2011