1. TLR4 Signaling Induces B7-H1 Expression Through MAPK Pathways in Bladder Cancer Cells
- Author
-
Junfang Deng, Junwei Liu, Shenyong Yin, Lin Zhou, Zhou Ye, Yan Wang, Guoping Jiang, Shusen Zheng, Yigang Qian, Lei Geng, Haiyang Xie, and Xiaowen Feng
- Subjects
Lipopolysaccharides ,MAPK/ERK pathway ,Cancer Research ,MAP Kinase Signaling System ,Pyridines ,Morpholines ,Lipopolysaccharide Receptors ,Biology ,B7-H1 Antigen ,Phosphatidylinositol 3-Kinases ,Immune system ,Antigen ,Antigens, CD ,Cell Line, Tumor ,medicine ,Humans ,Phosphorylation ,Extracellular Signal-Regulated MAP Kinases ,Receptor ,Protein Kinase Inhibitors ,Phosphoinositide-3 Kinase Inhibitors ,Anthracenes ,Flavonoids ,Carcinoma, Transitional Cell ,Bladder cancer ,Imidazoles ,JNK Mitogen-Activated Protein Kinases ,General Medicine ,medicine.disease ,Neoplasm Proteins ,Up-Regulation ,Cell biology ,Toll-Like Receptor 4 ,Urinary Bladder Neoplasms ,Oncology ,Chromones ,Cell culture ,TLR4 ,Protein Processing, Post-Translational ,Proto-Oncogene Proteins c-akt - Abstract
TLR4 (Toll-like receptor 4) and B7-H1, which were known to be restricted to immune cells in the past, were found to be aberrantly expressed in a majority of tumor cells, facilitating tumor evasion from immune surveillance. Our study demonstrated that activation of TLR4 signaling in bladder cancer cells up-regulated B7-H1 expression. Furthermore, this regulation was significantly attenuated by ERK or JNK inhibitor. Our results elucidated the molecule mechanism of regulation of B7-H1 expression through TLR4 signaling and may suggest new strategies of down-regulating the cancer-associated B7-H1 expression for bladder cancer treatment.
- Published
- 2008