1. Biological activities of unique isoflavones prepared from Apios americana Medik
- Author
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Masaya Imoto, Shun Saito, Manabu Kawada, Isao Momose, Haruna Kaneta, Mina Koda, Yoko Yamazaki, and Kazuoshi Shindo
- Subjects
Antioxidant ,medicine.drug_class ,medicine.medical_treatment ,Estrogen receptor ,Genistein ,Pharmacology ,01 natural sciences ,Applied Microbiology and Biotechnology ,Biochemistry ,Analytical Chemistry ,Androgen receptor binding ,chemistry.chemical_compound ,0404 agricultural biotechnology ,medicine ,Agonistic behaviour ,Molecular Biology ,biology ,010405 organic chemistry ,Chemistry ,business.industry ,Organic Chemistry ,Fabaceae ,04 agricultural and veterinary sciences ,General Medicine ,Apios ,Isoflavones ,biology.organism_classification ,040401 food science ,0104 chemical sciences ,Biotechnology ,Estrogen ,business - Abstract
Four unique isoflavone aglycones (barpisoflavone A (1), 2′-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1–4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities.
- Published
- 2016