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2 results on '"Aller Reyero MA"'

1. [Uretero-ureteral anastomosis in rats using a horizontal en-U suture].

Author

Rodríguez Gómez J, Arias Pérez J, Lorente Ruigómez L, Martínez Escandell A, Trobo Muñiz JI, Aller Reyero MA, Jiménez García-Alzórriz G, and Brandau Ballnet D

Subjects
Anastomosis, Surgical methods, Animals, Male, Microsurgery, Nephrectomy, Rats, Suture Techniques, Ureter surgery
Published
1987

2. [Effect of verapamil on hepatorenal toxicity induced by cyclosporin].

Author

Aller Reyero MA, Arias Pérez J, Lorente Ruigómez L, Arias Fernández L, Trovo Muñiz JI, Brandau Ballnet D, and Durán Sacristán H

Subjects
Animals, Female, Kidney pathology, Liver pathology, Rats, Rats, Inbred Strains, Cyclosporins toxicity, Kidney drug effects, Liver drug effects, Verapamil pharmacology
Abstract

The immunosuppressive and nephrotoxic effects of cyclosporine A (CsA) have been ascribed to a calcium-dependent mechanism of action. However, verapamil, a slow-calcium-channel blocking agent, enhances the immunosuppressive action of CsA and reduces its nephrotoxicity. The present experimental study performed in Wistar rats demonstrates that 0.1 mg..24 h.-1 IM verapamil prevents reduction of liver weight caused by treatment with 20 mg..kg.-1..24 h.-1 IM, as well as a rise in SGOT, SGPT, serum LDH and creatinine. The nephro-protective effects of verapamil in rats treated with CsA could be ascribable to the increased plasma clearance of the immunosuppressive agent.

Published
1989

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