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Various effects of exposure to volatile organic compounds (VOC) have recently become an important issue because of their widespread use in industry. The aim of this study was to determine the effect of volatile organic solvents commonly used in textile paint industry on free radical levels and the antioxidant enzyme system in textile workers. The study included twenty exposed workers and twenty controls. Blood samples were taken after an overnight fast of 10 to 12 hours. Malondialdehyde (MDA) and total antioxidant capacity (TAC) were studied in serum while super oxide dismutase (SOD) activity was studied in erythrocytes. Statistical analysis was performed using the ANOVA and Kruskall-Wallis analysis tests. MDA and SOD were significantly higher in textile workers than in controls (p0.05). Elevated MDA levels in textile workers may indicate increased lipid peroxidation as a result of long-term exposure to organic solvents, whereas elevated SOD activity suggests that the antioxidant system was activated to counter lipid peroxidation. The results suggest that textile workers occupationally exposed to volatile organic solvents make a risk group and require more frequent periodic examinations., Štetni učinci izloženosti hlapljivim organskim spojevima u novije su vrijeme razlog zabrinutosti zbog njihove sve veće uporabe u industriji. U ovome su istraživanju procjenjivane razine slobodnih radikala te aktivnost sustava antioksidacijskih enzima u uzorcima periferne krvi radnika zaposlenih u pogonima za bojenje tkanina izloženih hlapljivim organskim otapalima. Istraživanje je provedeno na dvadeset profesionalno izloženih ispitanika te dvadeset ispitanika kontrolne skupine. Uzorci periferne krvi svim su ispitanicima uzimani u jutarnjim satima, nakon 10 do12 sati gladovanja. Koncentracije malondialdehida (MDA) i ukupni antioksidacijski kapacitet mjereni su u serumu, a aktivnost super oksid dismutaze (SOD) u eritrocitima. Statistička analiza provedena je primjenom ANOVA i Kruskall-Wallisova testa. U skupini tekstilnih radnika utvr|ena je značajno povišena razina MDA u usporedbi s kontrolom (p