1. Challenges and Perspectives on Biosensors for Highly Sensitive Quantification of Salivary Troponins: A Review
- Author
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Susana Oliveira Catarino, Nuno Sousa, Graça Minas, Vitor Hugo Pereira, and Universidade do Minho
- Subjects
Engenharia e Tecnologia::Engenharia Médica ,medicine.medical_specialty ,Saliva ,Diseases ,macromolecular substances ,030204 cardiovascular system & hematology ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,Biotecnologia Médica [Ciências Médicas] ,cardiovascular disease ,medicine ,Electrical and Electronic Engineering ,Intensive care medicine ,Treatment costs ,Instrumentation ,Injuries ,Science & Technology ,Venipuncture ,biology ,microfluidic devices and lab-on-chip devices ,business.industry ,Myocardium ,010401 analytical chemistry ,Heart ,Engenharia Eletrotécnica, Eletrónica e Informática [Engenharia e Tecnologia] ,Engenharia Médica [Engenharia e Tecnologia] ,Serum concentration ,Troponin ,3. Good health ,0104 chemical sciences ,Highly sensitive ,Biosensors ,biology.protein ,Ciências Médicas::Biotecnologia Médica ,troponins ,business ,Biosensor ,Biomarkers ,Engenharia e Tecnologia::Engenharia Eletrotécnica, Eletrónica e Informática - Abstract
Troponins are recognized as one of the most specific and sensitive biomarkers for the diagnosis and prognosis of acute coronary syndromes. The use of troponins as acute cardiac isquemic biomarkers impacts positively on the treatment costs and on the mortality rate due to cardiovascular diseases. Nowadays, efforts have been made to develop new methods to detect and quantify troponins in a non-invasive way, reducing the need for blood samples and venipuncture. Saliva started to be increasingly recognized as an attractive diagnostic fluid. However, the challenges in achieving statistically significant correlations between saliva and serum concentrations, the limitations dealing with this high viscosity fluid and the background interferences, have limited the application of biosensors for troponin quantification in saliva. This review briefly approaches the mechanisms of troponin release and reports the methods found in literature for detection of troponin in saliva. Finally, the authors present a discussion of the challenges and perspectives on this topic., This work was supported by Portuguese FCT, under the reference project UIDB/04436/2020, and by Project NORTE-01-0145-FEDER-028178 funded by NORTE 2020 Portugal Regional Operational Program under PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund and the Fundação para a Ciência e Tecnologia
- Published
- 2021