Let (R, *) be a 2-torsion free *-prime ring with involution * and center Z(R), U a nonzero square closed *-Lie ideal of R. An additive mapping F : R→R is called a generalized derivation if there exits a derivation d : R→R such that F(xy)=F(x)y+xd(y). In the present paper, we prove that U ⊆ Z(R) if any one of following conditions holds: 1) [F (u), u] = 0, 2) [d(u), F(v) = 0, 3) d(u)oF(v) = 0; 4) [d(u), F(v)] = ±[u,v], 5) d(u)oF(v) = ±uov, 6) d(u)F(v)±uv ϵ Z(R), for all u, v ϵ U. Furthermore, an example is given to demonstrate that the *-primeness hypothesis is not superfluous. [ABSTRACT FROM AUTHOR]