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Oral cancer is a widespread and aggressive cancer with a greater rate of morbidity, mortalityand recurrence worldwide. Early diagnosis is of utmost significance for the prevention and management of cancer. Nanotechnology is a broad field that has pioneered the sectorand set modern trends in oral cancer management. Tissue biopsy is usually the fundamental basis for the diagnosis of oral cancer, but it is invasive and can cause discomfort to patient. Nano detection devices are recognized as recent emerging non-invasive approaches to nano scale biomarker sensitivity detection. Nanotechnology can help with less harmful substance to have a better diagnosis. Nanotechnology next- generation technology have many benefits in treating cancer patients during oral malignancy stages from diagnosis to therapy and monitoring disease. [ABSTRACT FROM AUTHOR]