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Your search keyword '"Vladimír Landa"' showing total 2 results
Start Over Author "Vladimír Landa" Publisher institute of physiology of the czech academy of sciences
2 results on '"Vladimír Landa"'

1. Sterol Regulatory Element Binding Protein 2 Overexpression Is Associated With Reduced Adipogenesis and Ectopic Fat Accumulation in Transgenic Spontaneously Hypertensive Rats

Author

Petr Mlejnek, Ludmila Kazdova, Michal Pravenec, Miroslava Šimáková, Jan Šilhavý, Jaroslava Trnovska, Vladimír Landa, and Vaclav Zidek

Subjects
Blood Glucose, medicine.medical_specialty, Physiology, medicine.medical_treatment, Adipose tissue, Biology, Carbohydrate metabolism, chemistry.chemical_compound, Spontaneously hypertensive rat, Rats, Inbred SHR, Internal medicine, medicine, Animals, Humans, Insulin, Promoter Regions, Genetic, Triglycerides, Fatty acid synthesis, Adiposity, Adipogenesis, Triglyceride, Cholesterol, Intracellular Signaling Peptides and Proteins, General Medicine, Disease Models, Animal, Endocrinology, Adipose Tissue, Liver, chemistry, Hypertension, Phosphoenolpyruvate Carboxykinase (GTP), Sterol regulatory element-binding protein 2, Rats, Transgenic, Sterol Regulatory Element Binding Protein 2
Abstract

It has been reported that the major function of the sterol regulatory element binding protein 2 (SREBP-2) is to activate preferentially cholesterol biosynthesis in liver and adipose tissue rather than fatty acid synthesis. In the current study, we analyzed the effects of overexpression of human dominant-positive SREBP-2 transgene under control of PEPCK promoter in the spontaneously hypertensive rat (SHR) on lipid and glucose metabolism. Transgenic overexpression of SREBP-2 was associated with significantly higher hepatic triglycerides (20.4+/-0.9 vs. 17.0+/-0.05 micromol/g, P

Published
2014
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2. Recent Progress in the Genetics of Spontaneously Hypertensive Rats

Author

Petr Mlejnek, Vladimír Křen, Vladimír Landa, Miroslava Šimáková, Alena Musilova, Vaclav Zidek, Jan Šilhavý, and Michal Pravenec

Subjects
Metabolic Syndrome, Genetics, Regulation of gene expression, Candidate gene, Physiology, Quantitative Trait Loci, Gene targeting, General Medicine, Biology, Quantitative trait locus, Proteomics, Genome, Rats, Spontaneously hypertensive rat, Species Specificity, Rats, Inbred SHR, Animals, Humans, Insulin Resistance, Rats, Transgenic, Gene
Abstract

The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and accompanying metabolic disturbances. Recent advances in sequencing of genomes of BN-Lx and SHR progenitors of the BXH/HXB recombinant inbred (RI) strains as well as accumulation of multiple data sets of intermediary phenotypes in the RI strains, including mRNA and microRNA abundance, quantitative metabolomics, proteomics, methylomics or histone modifications, will make it possible to systematically search for genetic variants involved in regulation of gene expression and in the etiology of complex pathophysiological traits. New advances in manipulation of the rat genome, including efficient transgenesis and gene targeting, will enable in vivo functional analyses of selected candidate genes to identify QTL at the molecular level or to provide insight into mechanisms whereby targeted genes affect pathophysiological traits in the SHR.

Published
2014
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