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The objective of this pilot study was to test the efficiency of a cognitivebehavioral psychological intervention, aimed at reducing emotional distress and improving quality of life in breast cancer patients undergoing radiotherapy. This was a quasi-experimental pretest/posttest study design, with a similar/equivalent control group (N=16, experimental group = 8, control group = 8). The statistical mixed design ANOVA method was used for univariate analysis of inter- and intra-group variability. Significant differences between the two groups with similar onset scores, were obtained at the end of the intervention at DT [F (1,14) = 13.63; η2 = 0.493 p = 0.002], FACT-B [t (14) = 4.55, p <0.001), CI = [13,542; 37708] ET: distress [t (14) = 5.50, p <0.001), CI = [- 819; 2069], anxiety [t (14) = - 0.15, p <0.001), CI = [- 6.81; -2.69], depression [t (14) = - 3.08, p = 0.008), CI = [- 5.73; -1.02], need help [t (14) = - 3.50, p =0.004), CI = [- 5.45; 1.30]. The interaction between time and intervention was significant for the level of emotional distress, depression, anxiety, event impact and quality of life. In conclusion, psychological group intervention can be a useful approach to increase the quality of life of breast cancer patients undergoing radiotherapy. The limitations of the study are related to the size of the sample, the compressed therapy sessions, and the absence of follow-up. [ABSTRACT FROM AUTHOR]