1. PDGFRα/HER2 and PDGFRα/p53 Co-expression in Oral Squamous Cell Carcinoma.
- Author
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Cierpikowski P, Lis-Nawara A, Gajdzis P, and Bar J
- Subjects
- Biomarkers, Tumor biosynthesis, Carcinoma, Squamous Cell pathology, Female, Head and Neck Neoplasms pathology, Humans, Immunohistochemistry, Male, Middle Aged, Mouth Neoplasms pathology, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell metabolism, Head and Neck Neoplasms metabolism, Mouth Neoplasms metabolism, Receptor, ErbB-2 biosynthesis, Receptor, Platelet-Derived Growth Factor alpha biosynthesis, Tumor Suppressor Protein p53 biosynthesis
- Abstract
Aim: The purpose of this study was to explore the parallel expression of platelet-derived growth factor receptor α (PDGFRα) and human epidermal growth factor receptor 2 (HER2) or p53 in relation to clinicopathological parameters of oral squamous cell carcinoma (OSCC) to define their role in progressive growth of tumor., Materials and Methods: Expression of PDGFRα, HER2 and p53 was evaluated in 71 OSCC samples by immunohistochemistry. HER2 status was verified by fluorescence in situ hybridization., Results: PDGFRα and p53 expression were associated with tumor grade (p=0.043 and p=0.040, respectively). HER2 expression was more frequent in advanced (III/IV) cancer (p=0.006). A positive correlation of PDGFRα with HER2 (r=0.267; p=0.024) and with p53 (r=0.266; p=0.025) was noted. PDGFRα/HER2 and PDGFRα/p53 co-expression was found more often in G3 than in G1 and G2 tumors (p=0.008 and p=0.015, respectively)., Conclusion: Our study revealed that PDGFRα/HER2 and PDGFRα/p53 co-expression exists in poorly differentiated OSCCs, suggesting that cooperation between these proteins might enhance aggressive behavior of tumor., (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2018
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