1. Association of Pro-apoptotic Bad Gene Expression Changes with Benign Thyroid Nodules.
- Author
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Gül N, Temel B, Ustek D, Sirma-Ekmekçi S, Kapran Y, Tunca F, Giles-Şenyürek Y, Özbek U, and Alagöl F
- Subjects
- Adult, Aged, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Neoplasm Grading, Proto-Oncogene Proteins c-bcl-2 genetics, Proto-Oncogene Proteins c-bcl-2 metabolism, Young Adult, bcl-2-Associated X Protein genetics, bcl-2-Associated X Protein metabolism, bcl-Associated Death Protein metabolism, Apoptosis genetics, Thyroid Neoplasms genetics, Thyroid Neoplasms pathology, Thyroid Nodule genetics, Thyroid Nodule pathology, bcl-Associated Death Protein genetics
- Abstract
Background/aim: This study aimed to investigate the role of the mitochondrial apoptotic pathway in benign thyroid nodules., Materials and Methods: Paired samples of nodular and normal tissues were collected from 26 patients with nodular goiters undergoing thyroidectomy. Variable expression of Bcl-2, Bax and Bad genes were evaluated by quantitative PCR., Results: Expression level of Bad gene in nodules was found to be significantly decreased compared to normal tissues (p=0.049). A positive correlation was observed between nodule size and Bad expression levels (correlation coefficient=0.563, p=0.004); and this correlation was stronger in hot nodules (n=18, correlation coefficient=0.689, p=0.003). No significant difference was observed between nodular and normal tissue expressions of Bax and Bcl-2., Conclusion: These results suggest that Bad expression correlates with the size of benign thyroid nodules and also its relatively lower expression in nodules, warrant further investigation., (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2018
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