1. Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases
- Author
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Guangxun Zhu, Nian Liu, and Bin Zhou
- Subjects
Chemistry ,Matrix metalloproteinase inhibitor ,Cell ,Reversion ,030206 dentistry ,General Medicine ,Hypothesis ,Matrix Metalloproteinase Inhibitors ,Matrix metalloproteinase ,GPI-Linked Proteins ,Kazal Motifs ,Matrix Metalloproteinases ,Extracellular Matrix ,Cell biology ,Cysteine rich protein ,Extracellular matrix ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Matrix Metalloproteinase 14 ,medicine ,Humans ,Signal transduction ,Periodontal Diseases - Abstract
Periodontal diseases are characterized by pathological destruction of extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) are a significant part of the degradation of ECM. However, the regulation of MMPs expression level in periodontal diseases is as yet undetermined. RECK (reversion-inducing cysteine-rich protein with Kazal motifs), a novel membrane-anchored inhibitor of MMPs, could regulate the expressions of MMP-2, 9 and MT1-MMP as a cell surface-signaling molecule. Thus, we propose that RECK may play an important role in regulating MMPs in the ECM degradation of periodontal diseases. The RECK/MMPs signaling pathway could provide a new approach for prevention and treatment of RECK in periodontal diseases by blocking MMPs.
- Published
- 2016
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