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Background: Lynch syndrome (HNPCC, hereditary non-polyposis colorectal cancer) is a syndrome of predisposition to cancer inherited in an autosomal dominant fashion. A person with Lynch syndrome has a considerably increased risk of colorectal cancer in comparison with the general population., Case Report: We present a case of a 24-year-old man with Lynch syndrome (carrying an MLH1 gene mutation) who had colorectal adenocarcinoma diagnosed at 16 years of age. During this time, he had a colectomy performed and chemotherapy was administered (5-FU, CDDP, Leucovorin). Due to hepatic metastases, a decision was made to change chemotherapy to IF with ADM, as a result of which complete remission was obtained. However, kidney failure developed. Its cause was not fully elucidated. The patient was treated by hemodialyses. After six years of complete remission of cancer, kidney transplantation started to be considered. Before the patient was found eligible for transplantation, extended diagnostic tests were performed: whole body PET scan, tumour marker tests and intestinal endoscopy, which did not reveal any abnormalities. The patient had a family donor (mother) who had no contraindications to kidney donation. Kidney transplantation was performed on 15/10/2012. Induction with basiliximab was used, along with steroids, tacrolimus, and mycophenolate mofetil was also administered. Three months after the procedure CNI/mTOR conversion was performed. The maintenance treatment includes prednisone, everolimus and mycophenolate mofetil. One year after transplantation, renal function is normal. The patient is subjected to close oncological surveillance., Conclusions: The risk of recurrence or new development of cancer related to immunosuppressive treatment should be considered on a case-by-case basis. In patients with a history or high risk of cancer, immunosuppression protocols based on the m-TOR pathway inhibitors should be used, if possible. Oncological surveillance and early detection of new cancer lesions are also important.

Background: The living kidney donor is exposed to the renal function impairment as a result of kidney donation, which may increase the risk of cardiovascular diseases. It seems justified to identify cardiovascular risk factors prior to kidney donation., Material and Methods: We analyzed data of 50 consecutive potential kidney donors. All individuals underwent clinical examination and lipid profile. For each subject we calculated atherogenic index. To calculate the 10-year risk of cardiovascular death, the HeartScore calculator was used., Results: The most frequent risk factors were obesity, lipid disorders, and smoking. In 72% of subjects, at least 1 of the risk factors was detected. Atherogenic index values considered to indicate high risk of atherosclerosis were found in 16% of subjects. More than 40% of subjects had more than 1 coronary risk factor, and most had 2. In 58% of subjects, the calculated HeartScore risk value was consistent with risk estimated for age, and in 26% it exceeded this value by 1-9% (mean, 3.1%)., Conclusions: The prevalence of coronary risk factors is high in potential kidney donors. HeartScore seems to be a useful method to evaluate the risk of cardiovascular mortality in these individuals, and is a simple tool to use in controlling the influence of the modification of risk factors on the global risk in follow-up. Comparison with the value of risk acceptable according to age and sex may oblige the physician to take action to reduce it.