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The title compound, C51H78INO12, contains a 29-membered ring incorporating amide, lactone and ester groups. It contains a total of 15 stereogenic centres. In the crystal, molecules are linked by O—H...O hydrogen bonds, forming C(8) chains propagating in [100]. A weak intramolecular O—H...O interaction also occurs.

The title compound, C51H78N4O12, is a derivative of rapamycin, a triene macrolide antibiotic molecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hydroxy groups giving an intramolecular hydrogen bond to a ketone O-atom acceptor. The molecules also form intermolecular hydroxy–ketone O—H...O hydrogen-bonding associations, giving one-dimensional chains extending along (010). The crystal has 108 Å3 solvent-accessible voids.

In the title compound, C15H23N3O4, the six-membered pyran, cyclohexane and trioxane rings adopt chair, chair and boat conformations, respectively, while the seven-membered rings adopt distorted boat and very distorted chair conformations. In the crystal, adjacent molecules are connected by weak C—H...N and C—H...O interactions.