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The experiment used white mice, which were divided into 4 groups. The first group of mice was injected with a saline solution with 0.04 mg of Trichinella antigen obtained by the Magat method subcutaneously, the second group of mice was injected with azoxymer bromide (polyoxidonium) at a dose of 0.004 mg/mouse, the third group was infected with Trichinella larvae without preliminary administration of drugs, group 4 served as a control. A week after the last injection of drugs, mice were infected with invasive Trichinella larvae at a dose of 40 larvae/animal. Evaluation of the protective properties of polyoxidonium in laboratory models was carried out by determining the intensity of invasion in studies of all muscle groups of the animal by the method of peptolysis and histological material to assess the cellular composition of the spleen. The protective effectiveness of polyoxidonium was 99.43%. The rearrangement of the structure of the spleen under the influence of an immunostimulant indicated a high degree of reactivity of the spleen of animals in response to the introduction of polyoxidonium (the ratio of red and white pulp and their cellular composition changes).