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The detection of gene-environment (GE) interactions is very important for dealing with complex diseases. Although some methods have been proposed to detect the interactions between genes and the environment, however, in the case of rare variants, these methods are limited. In this paper, we extend the existing ADA method and proposed a combined strategy (i-ADA) to identify the gene-environment interaction for rare variants. Firstly, we use Levene test to test the equality of variances under different sites. Secondly, based on the first-sep P-values and combined with the ADA method, we design a novel interaction test. Finally, we use the GAW17 dataset to illustrate the practicality of the proposed method.

With the development of air transport industry in China, the congestion problem in the terminal areas of busy airports has become increasingly serious. In order to alleviate the increasingly frequent air traffic congestion, it is necessary to accurately and objectively predict traffic flow. Traditionally, most predicted methods are based on the number of aircrafts flight in the terminal area to obtain deterministic traffic flow data, without considering the impact of uncertain factors on the prediction results. Based on the uncertainty of demand, this paper uses a probability density prediction method based on quantile regression neural network and kernel density estimation, to analyse the variation of traffic flow at different quantiles according to the obtained continuous conditional quantile function. Predicting the probability density of traffic flow on a certain day, and then comparing the point prediction value corresponding to the peak value, which consider the weather factor and the conditional probability density prediction curve without considering the weather factor, it is concluded that considering the weather factor can make the traffic flow prediction more accurate.