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3 results on '"Li WN"'

1. Elevated growth differentiation factor 15 expression predicts poor prognosis in epithelial ovarian cancer patients.

Author

Zhang Y, Hua W, Niu LC, Li SM, Wang YM, Shang L, Zhang C, Li WN, Wang R, Chen BL, Xin XY, Zhang YQ, and Wang J

Subjects
Adenocarcinoma, Mucinous metabolism, Adenocarcinoma, Mucinous therapy, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cystadenocarcinoma, Serous metabolism, Cystadenocarcinoma, Serous therapy, Endometrial Neoplasms metabolism, Endometrial Neoplasms therapy, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Immunoenzyme Techniques, Lymphatic Metastasis, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local metabolism, Neoplasm Recurrence, Local therapy, Neoplasm Staging, Ovarian Neoplasms metabolism, Ovarian Neoplasms therapy, Prognosis, Survival Rate, Adenocarcinoma, Mucinous pathology, Biomarkers, Tumor metabolism, Cystadenocarcinoma, Serous pathology, Endometrial Neoplasms pathology, Growth Differentiation Factor 15 metabolism, Neoplasm Recurrence, Local pathology, Ovarian Neoplasms pathology
Abstract

The purpose of this study was to determine the expression of growth differentiation factor 15 (GDF15) and explore its clinical significance in epithelial ovarian cancer (EOC) patients. The expression of GDF15 in EOC tissues and serum samples was evaluated using immunohistochemistry and enzyme-linked immunosorbent assay (ELISA), respectively. The association of GDF15 expression with clinicopathologic parameters was analyzed. Survival time was assessed using the Kaplan-Meier technique and Cox regression model. Both in EOC tissues and serum, high GDF15 levels were obviously related with advanced International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, ascites, and chemoresistance. Kaplan-Meier analysis indicated that EOC patients with high GDF15 expression showed poorer progression-free survival (PFS) and overall survival (OS). Multivariate analysis demonstrated that GDF15 expression was an independent predictor of PFS in EOC patients. Our study shows that elevated GDF15 expression was associated with poor prognosis in EOC patients. We suggest that GDF15 is a novel biomarker for the early detection of EOC, prediction of the response to chemotherapy, and screening for recurrence in EOC patients.

Published
2016
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3. The high expression of TC1 (C8orf4) was correlated with the expression of β-catenin and cyclin D1 and the progression of squamous cell carcinomas of the tongue.

Author

Zhang P, Cao HY, Bai LL, Li WN, Wang Y, Chen SY, Zhang L, Yang LH, Xu HT, and Wang EH

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell pathology, Carrier Proteins biosynthesis, Carrier Proteins genetics, Cyclin D1 genetics, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Neoplasm Proteins genetics, Neoplasm Staging, Nuclear Proteins biosynthesis, Nuclear Proteins genetics, Tongue Neoplasms pathology, Wnt Signaling Pathway, beta Catenin genetics, Carcinoma, Squamous Cell genetics, Cyclin D1 biosynthesis, Neoplasm Proteins biosynthesis, Tongue Neoplasms genetics, beta Catenin biosynthesis
Abstract

Thyroid cancer 1 (TC1, C8orf4) plays important roles in many signaling pathways, such as Wnt/β-catenin signaling pathway, and is involved in the development of many cancers. The objective of this study was to examine the expression of TC1 and investigate the associations among TC1, β-catenin, Chibby, cyclin D1, and the clinicopathological factors of oral tongue squamous cell carcinomas (OTSCCs). The expressions of TC1, β-catenin, Chibby, and cyclin D1 were examined in 109 cases of OTSCCs using immunohistochemistry. The expression of TC1 was observed in all cases of OTSCCs but was negative or weak in normal squamous epithelial tissues of tongue. The high expression of TC1 was correlated with the advanced TNM stage (P = 0.042), the abnormal expression of β-catenin (correlation coefficient = 0.314, P = 0.001) and the expression of cyclin D1 (correlation coefficient = 0.274, P = 0.006) in OTSCCs. But we did not find any associations between TC1 and Chibby. The abnormal expression of β-catenin was correlated with the poor differentiation (P = 0.035), advanced TNM stage (P = 0.048) and the expression of cyclin D1 (correlation coefficient = 0.422, P < 0.001). In conclusion, the high expression of TC1 was common in OTSCCs and correlated with the expression of β-catenin and cyclin D1 and the progression of OTSCCs. The high expression level of TC1 might promote the progression of OTSCCs by enhancing the activity of Wnt signaling pathway.

Published
2015
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